grant
Speeding Immune Reconstitution after Thymus Transplantation
NIHUS FederalResearch GrantFY2026(IFN) α(IFN)-α(IFN)α0-11 years old4 year old4 years of ageAAV vectorAAV-based vectorAdolescentAdolescent YouthAffectAlferonAllogeneic TransplantationAntigensArchitectureAthymic MiceAthymic Nude MouseAutoimmune StatusAutoimmunityAutoregulationB Cells Mixed T CellsBCL1BiologyBone MarrowBone Marrow Reticuloendothelial SystemCCND1CCND1 ProteinCCND1 geneCancer TreatmentCancersCapsidCardiac TransplantationCause of DeathCell CountCell NumberCell ProtectionCessation of lifeCharacteristicsChildChild YouthChildren (0-21)Clinical TreatmentCommon Rat StrainsCyclin D1Cyclin D1 GeneCytoprotectionD11S287EDNA TherapyDNA cassetteDataDeathDonor personDrug TherapyEngineering / ArchitectureExhibitsFDA approvedFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryG1/S-Specific Cyclin D1Gene Transfer ClinicalGeneralized GrowthGenetic InterventionGoalsGrafting ProcedureGrowthHeartHeart GraftingHeart TransplantationHomeostasisHomologous TransplantationHumanIFNIFN AlphaIFN αIFN-GammaIFN-gIFN-αIFN-γIFNGIFNaIFNαIFNγImmune InterferonImmune responseImmune systemImmunityImmunocompetentImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImplantInfantInfectionInterferon Alfa-n3Interferon GammaInterferon Type IIInterferon-αInterferonsInterventionJAK-2JAK1JAK1 geneJAK1 proteinJAK1AJAK2JAK2 geneJAK2 proteinJak1 kinaseJanus kinase 1Janus kinase 2K5 keratinLeadLeukocyte InterferonLifeLymphoblast InterferonLymphoblastoid InterferonMHC antigenMLC testMLR testMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMeasuresMethodsMiceMice MammalsMixed Leukocyte Culture TestMixed Leukocyte ReactionMixed Lymphocyte CultureMixed Lymphocyte Culture TestMixed Lymphocyte ReactionModern ManMurineMusNude MiceOrgan TransplantationOrgan TransplantsPRAD1PRAD1 ProteinPathway interactionsPatientsPb elementPerinatalPeripartumPharmacological TreatmentPharmacotherapyPhenotypePhysiological HomeostasisProcessProductionProgenitor CellsProliferatingProto-Oncogene Proteins c-bcl-1QualifyingRatRats MammalsRattusResearchSelf ToleranceSignal PathwaySpeedT cell reconstitutionT-Cell DevelopmentT-Cell OntogenyT-CellsT-LymphocyteT-Lymphocyte DevelopmentThymic TissueThymic epithelial cellThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTimeTissue GrowthTransgenic MiceTransgenic OrganismsTranslatingTransplant RecipientsTransplantationTyrosine-Protein Kinase JAK1Tyrosine-Protein Kinase JAK2U21B31VaccinationViral VectorWeightWorkadeno-associated viral vectoradeno-associated virus vectorage 4age 4 yearsage associated declineage dependent declineage related declineanti-cancer therapyathymiabcl-1 Proto-Oncogene Productsbcl-1 Proto-Oncogene Proteinsbcl1 Proto-Oncogene Proteinsc-bcl-1 Proteinscancer therapycancer-directed therapycardiac damagecardiac graftclinical interventionclinical therapycyclin Dcytokinecytoprotectivedecline with agedevelop therapydrug interventiondrug treatmentenhancer cassetteexperienceexpression cassetteflow cytophotometryfour year oldfour years of agegene cassettegene repair therapygene therapygene-based therapygenetic cassettegenetic therapygenomic therapyheart damageheart transplantheavy metal Pbheavy metal leadhost responsehypoimmunityimmune competentimmune deficiencyimmune reconstitutionimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunodeficiencyimmunogenimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimplantationimprovedinhibitorintegration cassetteintervention developmentjuvenilejuvenile humankeratin 5kidslFN-Gammamalignancymixed lymphocyte reaction testmouse modelmurine modelneoplasm/cancernovelontogenyorgan allograftorgan graftorgan transplant patientorgan transplant recipientorgan xenograftoverexpressoverexpressionpathwayperinatal periodperinatal phaseperipheral bloodpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreventpreventingprogramspromoterpromoter cassettepromotorrational designreporter cassetteresistance cassettescRNA sequencingscRNA-seqselectable cassetteselection cassettesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstem cellsstop cassettesuccesstherapy developmentthymocytethymus derived lymphocytethymus transplantationtranscription cassettetranscriptional cassettetransgene cassettetransgenictransplanttransplant donortransplant patienttreatment developmenttreatment effecttrial regimentrial treatmentweightsyoungster
Description preview
ABSTRACT: Speeding Immune Reconstitution after Thymus Transplantation
Pivotal prior work by our team showed that cultured thymus tissue implantation (CTTI; also called thymus
transplantation) into athymic humans generates a functional immune system where T cells protect against
infection and are tolerant to both recipient (self) and to donor MHC…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click