grant
Specialization and targeting of CD4+ tissue resident memory T cells in EAE
Organization BENAROYA RESEARCH INST AT VIRGINIA MASONLocation SEATTLE, UNITED STATESPosted 22 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AddressAffectAllelesAllelomorphsAnimal ModelAnimal Models and Related StudiesAttenuatedAutoimmuneAutoimmune DiseasesAutoimmune StatusAutoimmunityAxonBasal Transcription FactorBasal transcription factor genesBehaviorBloodBlood Reticuloendothelial SystemBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8BCD8B1CD8B1 geneCNS DiseasesCNS Nervous SystemCNS autoimmune diseaseCNS autoimmunityCNS disorderCRE RecombinaseCell BodyCellsCentral Nervous SystemCentral Nervous System DiseasesCentral Nervous System DisordersCerebrospinal FluidCharacteristicsChemokine Receptor GeneChronicCirculationCorynebacterium Diphtheriae ToxinDNA cassetteDemyelinationsDependenceDevelopmentDiphtheria ToxinDiseaseDisorderDisseminated SclerosisEAEEnterobacteria phage P1 Cre recombinaseExperimental Allergic EncephalitisExperimental Allergic EncephalomyelitisExperimental Autoimmune EncephalitisExperimental Autoimmune EncephalomyelitisFP593General Transcription Factor GeneGeneral Transcription FactorsGenesGeneticHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHeterogeneityIndividualInducer CellsInducer T-LymphocytesInfectionInflammationInvadedKnock-inLYT3Length of LifeLongevityMS patientMS treatmentMaintenanceMediatingMemoryMetabolicMiceMice MammalsModelingMouse StrainsMultiple SclerosisMurineMusNeuraxisPathogenesisPhenotypePredispositionRecoveryRoleSusceptibilityT memory cellT-CellsT-LymphocyteT4 CellsT4 LymphocytesTamoxifenTeff cellTestingTissuesTranscription Factor Proto-OncogeneTranscription factor genesTreatment EfficacyVariantVariationantigen challengeattenuateattenuatesautoimmune conditionautoimmune disorderautoimmune encephalomyelitisautoimmunity diseaseautoreactive T cellbacteriophage P1 recombinase Crebrain parenchymacentral nervous system autoimmune diseasecentral nervous system autoimmunitycerebral spinal fluidchemokine receptorcytokinedemyelinatedesigndesigningdevelopmentaldifferential expressiondifferentially expresseddisabilitydrFP583ds red proteindsFP593effector T cellenhancer cassetteexpression cassettegene cassettegene locusgenetic cassettegenetic locusgenomic locationgenomic locusinduced Creinducible Creinsular sclerosisintegration cassetteintervention efficacyknockinmemory CD4 T cellmemory CD4 T lymphocytememory T lymphocytemodel of animalmultiple sclerosis patientmultiple sclerosis therapymultiple sclerosis treatmentnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypatients with MSpatients with multiple sclerosispeople with Multiple sclerosisprogramspromoter cassettered fluorescent proteinreporter cassetteresidenceresident memory T cellresidential buildingresidential siteresistance cassettesecondary lymph organsecondary lymphatic organsecondary lymphoid organselectable cassetteselection cassetteself-reactive T cellsocial rolespinal fluidstop cassettetherapeutic efficacytherapy efficacythymus derived lymphocytetissue resident memory T celltooltranscription cassettetranscription factortranscriptional cassettetranscriptional differencestransgene cassette
Description preview
Project Summary
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized
by demyelination, axonal loss, and progressive disability. Similarly, its animal model, experimental autoimmune
encephalomyelitis (EAE) is marked by CNS inflammation and demyelination. Circulating CD4+ T helper (Th)
subsets have long…
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