grant
Spatiotemporal Regulation of Developmental Pattern Formation
Organization BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)Location BOSTON, UNITED STATESPosted 15 Dec 2023Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAlgorithmic AnalysesAlgorithmic AnalysisAnalyses of AlgorithmsAnalysis of AlgorithmsApproaches to preventionBirth DefectsBody TissuesCell BodyCell Communication and SignalingCell SignalingCellsComplexComputer ModelsComputerized ModelsCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCuesData AnalysesData AnalysisDevelopmentDevelopmental ProcessEchinoideaEctodermEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEmbryonic Pattern FormationEmbryonic Pattern SpecificationFoundationsGoalsHealthHumanInfant MortalityInfant Mortality TotalInstructionIntracellular Communication and SignalingKnowledgeLabelMapsMediatingMissionModelingModern ManMolecularMorphogenesisNIGMSNational Institute of General Medical SciencesNetwork AnalysisOutcomePathway AnalysisPatternPattern FormationPrevention approachProcessProductionPublic HealthRegulationResearchRoleSea UrchinsSignal TransductionSignal Transduction SystemsSignalingSkeletonSystems BiologyTissuesbiological signal transductioncomputational modelingcomputational modelscomputer based modelscomputerized modelingconfocal imagingdata interpretationdeath among infantsdeath in first year of lifedeath in infancydeath in infantsdevelopmentalgene regulatory networkinfant deathinfant demiseinfantile deathinnovateinnovationinnovativeinsightmorphogenetic processmortality in infantsnetwork modelsnew approachesnovelnovel approachesnovel strategiesnovel strategypreventpreventingresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskeletalskeletonssocial rolespatial and temporalspatial temporalspatiotemporalthree dimensionaltime usetool
Description preview
Project Summary/Abstract
Despite their important role in birth defects and infant mortality, the 3-D and 4-D patterning
processes that employ multiple signals to drive embryonic development and morphogenesis are
not mechanistically understood. The long-term goal is to obtain a complete molecular description
of 4-D pattern formation, using the…
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