grant
Spatialomics and quantitative MRI of ischemic injury in a piglet model of Legg-Calve-Perthes disease
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAcuteAddressAdultAdult HumanAffectAnimal ModelAnimal Models and Related StudiesAppearanceAppointmentAttentionAutomobile DrivingBilateralBiological FunctionBiological MarkersBiological ProcessBiologyBleedingBody TissuesBone-Derived Transforming Growth FactorCartilageCartilage injuryCartilaginous TissueCell Communication and SignalingCell MaturationCell SignalingCharacteristicsChildChild CareChild HealthChild YouthChildhoodChildren (0-21)ChondrocytesClinicalClinical ManagementClinical SciencesComplicationConsensusContralateralCoxaCoxa PlanaDataDedicationsDevelopmentDiagnostic MethodDiagnostic ProcedureDiagnostic TechniqueDiseaseDisease ProgressionDisorderDoctor of PhilosophyDown-RegulationDysfunctionEarly DiagnosisEducational process of instructingEducational workshopEpiphyseal PlateEpiphysial cartilageEvidence based treatmentExpression SignatureFacultyFamily suidaeFemurFoundationsFunctional disorderFundingGene ExpressionGene Expression ProfileGene TranscriptionGeneralized GrowthGenesGenetic TranscriptionGenomicsGoalsGrowthGrowth PlateHemorrhageHipHip region structureHistologicHistologicallyHistologyImaging ProceduresImaging TechnicsImaging TechniquesInjuryInterventionIntracellular Communication and SignalingInvestigatorsIschemiaK01 AwardK01 MechanismK01 ProgramKnowledgeLeadershipLearningLegLegg Calve Perthes diseaseLegg-Perthes DiseaseLengthMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMentored Research Scientist Development AwardMentored Training AwardMentorsMethodsMicroscopicMilk Growth FactorMolecularMorphologyMusculoskeletalNMR ImagingNMR TomographyNeckNuclear Magnetic Resonance ImagingOperative ProceduresOperative Surgical ProceduresOrthopedicOrthopedic SurgeryOrthopedic Surgical ProfessionOrthopedicsOutcomePainPainfulPathogenesisPathologyPathway interactionsPatientsPatternPerfusionPerthes DiseasePh.D.PhDPhysiologic OssificationPhysiological OssificationPhysiopathologyPigsPlatelet Transforming Growth FactorPositionPositioning AttributePuericultureRNA ExpressionRadiographyRecoveryRelaxationResearchResearch PersonnelResearch Scientist Development AwardResearchersRheumatologyRoentgenographyRoleSecondary toSignal TransductionSignal Transduction SystemsSignalingSiteSpecialtySuidaeSurfaceSurgeonSurgicalSurgical InterventionsSurgical ProcedureSwineTGF BTGF-betaTGF-βTGFbetaTGFβTeachingTechniquesThickThicknessTimeTissue GrowthTissuesTrainingTranscriptionTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTreatment ProtocolsTreatment RegimenTreatment ScheduleUncertaintyUpregulationVascular blood supplyWorkWorkshopZeugmatographyadulthoodbio-markersbiologic markerbiological signal transductionbiomarkerblood lossblood supplycandidate biomarkercandidate markercareercartilage repairclinical careconferenceconventiondevelopmentaldiagnostic profilediagnostic signaturedifferential expressiondifferentially expresseddisease modeldisorder modeldoubtdrivingearly detectioneffective therapyeffective treatmentexperiencefemur headgene expression patterngene expression signaturegene signaturesgenetic signaturegenomic datagenomic datasethigh riskimprovedinjuriesinsightischemia injuryischemic injurykidsknowledge basemedical specialtiesmembermodel of animalmusculoskeletal imagingmusculoskeletal scanningmusculoskeletal visualizationnormal ossificationnovelontogenyossificationpathophysiologypathwaypediatricpig modelpiglet modelporcineporcine modelpreservationpreventpreventingprogramspseudocoxalgiaradiological imagingrepairrepairedresponsesocial rolesuidsummitsurgeryswine modelsymposiasymposiumtenure processtenure tracktherapeutic targettranscriptional differencestranscriptional profiletranscriptional signaturetranscriptomicstranslational opportunitiestranslational potentialvascular supplyyoungster
Description preview
PROJECT SUMMARY
This K01 award will provide training and protected research time for Alexandra Armstrong, DVM, DACVP, PhD
to achieve her career goal of becoming an independently-funded investigator with specialty expertise in animal
models of developmental orthopedic diseases, including the application of spatialomic profiling and quantitative…
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