grant
Spatial genomic tools to interrogate T cell clonotypes, tumor clones and the microenvironment
Organization BROAD INSTITUTE, INC.Location CAMBRIDGE, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025AddressAdoptive TransferAffectAntigen TargetingAntigenic DeterminantsAntigensAttentionAutomobile DrivingBinding DeterminantsBiologicalBody TissuesCancersCell BodyCellsClinicalClinical PathologyClinical ProtocolsClone CellsCloningComplexCuesDNADNA mutationDNA seqDNA sequencingDNAseqDataDeoxyribonucleic AcidDetectionDevelopmentEpitopesGene TranscriptionGeneralized GrowthGenerationsGenetic ChangeGenetic HeterogeneityGenetic TranscriptionGenetic defectGenetic mutationGenomicsGoalsGrawitz TumorGrowthHistologicHistologicallyHumanHypernephroid CarcinomaHypernephromaImageImmuneImmune mediated therapyImmune responseImmune systemImmunesImmunityImmunologically Directed TherapyImmunotherapyIn SituInfiltrationKnowledgeLinkMHC ReceptorMajor Histocompatibility Complex ReceptorMalignantMalignant - descriptorMalignant MelanomaMalignant NeoplasmsMalignant TumorMapsMediatingMelanomaMemoryMethodsMiceMice MammalsMicroscopyModelingModern ManMolecularMurineMusMutationNatureNephroid CarcinomaNon-Polyadenylated RNAOutcomePatternPeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPhenotypePopulationPositionPositioning AttributeRNARNA ExpressionRNA Gene ProductsRNA SeqRNA sequencingRNAseqRenal AdenocarcinomaRenal Cell AdenocarcinomaRenal Cell CancerRenal Cell CarcinomaResearch SpecimenResolutionRibonucleic AcidRoleSamplingScienceSlideSpace PerceptionSpatial DiscriminationSpecificitySpecimenStromal CellsSystemT Cell SpecificityT cell infiltrationT cell receptor repertoire sequencingT cell receptor sequencingT cell responseT-Cell Antigen Receptor SpecificityT-Cell Antigen ReceptorsT-Cell Immunologic SpecificityT-Cell ReceptorT-Cell Receptor SpecificityT-CellsT-LymphocyteTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTechnologyTestingTissue GrowthTissuesTranscriptTranscriptionTumor AntigensTumor CellTumor ImmunityTumor TissueTumor-Associated AntigenVaccinesViralViral AntigensWorkanalytical toolanti-tumor immunityantitumor immunitybiologiccancer antigenscancer immunitycancer immunologycancer infiltrating T cellscancer microenvironmentcancer progressioncheck point blockadecheckpoint blockadecomputational infrastructurecomputer infrastructuredetection sensitivitydevelopmentaldisease controldisorder controldrivingexhaustgenome mutationgenome scalegenome-widegenomewidegenomic toolsglobal gene expressionglobal transcription profilehost responseimagingimmune check point blockadeimmune checkpoint blockadeimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunogenicimmunoresponseimprovedinsightkidney adenocarcinomamalignancyneo-antigenneo-antigen vaccineneo-epitopesneoantigen vaccineneoantigensneoepitopesneoplasm immunologyneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionontogenyoverexpressoverexpressionpMHCparallelizationperceptual spatial orientationreconstructionresolutionsresponse to therapyresponse to treatmentsocial rolespatial integrationspatial orientationspatial perceptionspatial relationshipsuccesstherapeutic responsetherapy responsethymus derived lymphocytetooltranscriptometranscriptome sequencingtranscriptomic sequencingtreatment responsetreatment responsivenesstumortumor immunologytumor infiltrating T cellstumor microenvironmenttumor progressiontumor-specific antigenvirus antigen
Description preview
The contemporary clinical successes of immunotherapies have highlighted the key role of tumor-infiltrating cells
in mediating anti-tumor immunity and have generally associated the presence of T cells within tumors with
therapeutic response. However, until now, a systematic approach for evaluating how T cell state, their clonal
identity and…
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