grant
Spatial functional genomics to identify regulators of the tumor microenvironment and cancer immunity
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 19 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AffectAnti-AngiogenesisAntiangiogenesisAntibodiesArchitectureBreast CancerCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCRISPRCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas systemCRISPR/Cas9 screenCancer BiologyCancer GenesCancer TreatmentCancer-Promoting GeneCancersCandidate Disease GeneCandidate GeneCategoriesCell BodyCell CommunicationCell CycleCell DeathCell Division CycleCell FractionCell InteractionCell membraneCell-to-Cell InteractionCellsChemotactic CytokinesClustered Regularly Interspaced Short Palindromic RepeatsCollagenCollectionComplementary DNAComputer AnalysisCytoplasmic MembraneDNA AlterationDNA Sequence AlterationDNA mutationDataDevelopmentDrug TargetingDrugsEngineering / ArchitectureEnvironmentFibroblastsGene ExpressionGeneralized GrowthGenesGenetic AlterationGenetic ChangeGenetic defectGenetic mutationGenomicsGoalsGrowthHead and Neck CancerHead and Neck CarcinomaHomologous Chemotactic CytokinesImmuneImmune SurveillanceImmune mediated therapyImmunesImmunityImmunocompetentImmunologic SurveillanceImmunologically Directed TherapyImmunosurveillanceImmunotherapyIn SituInfiltrationIntercrinesInvadedKnock-outKnockoutKnowledgeLigandsMachine LearningMacrophageMalignant Breast NeoplasmMalignant CellMalignant Head and Neck NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant Pancreatic NeoplasmMalignant TumorMalignant Tumor of the LungMalignant Tumor of the OvaryMalignant neoplasm of lungMalignant neoplasm of ovaryMalignant neoplasm of pancreasMapsMeasuresMediatingMedicationMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorModelingMorphologyMutateMutationMφNSCLCNSCLC - Non-Small Cell Lung CancerNeoplasm MetastasisNon-Small Cell Lung CancerNon-Small-Cell Lung CarcinomaOncogenesOral Cavity Squamous Cell CarcinomaOral squamous cell carcinomaOutcome StudyOvarian Serous AdenocarcinomaOvarian Serous CarcinomaOvary CancerPancreas AdenocarcinomaPancreas CancerPancreas Ductal AdenocarcinomaPancreatic AdenocarcinomaPancreatic CancerPancreatic Ductal AdenocarcinomaPatientsPharmaceutical PreparationsPhenotypePlasma MembranePositionPositioning AttributeProcessPublishingPulmonary CancerPulmonary malignant NeoplasmResistanceResolutionRoleSIS cytokinesSecondary NeoplasmSecondary TumorSelection for TreatmentsSequence AlterationSerousSerous Adenocarcinoma of the OvarySerous Carcinoma of the OvarySolid NeoplasmSolid TumorT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-cell therapeuticsT-cell transfer therapyT8 CellsT8 LymphocytesTCGATestingThe Cancer Genome AtlasTissue GrowthTransforming GenesTumor BiologyTumor ImmunityTumor ProcessTumor-Associated Processadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyanti-angiogenesis therapyanti-cancer therapyanti-tumor immunityantiangiogenesis therapyantitumor immunitycDNAcancer cellcancer imagingcancer immunitycancer metastasiscancer microenvironmentcancer therapycancer-directed therapycandidate identificationcell stromacheck point blockadecheckpoint blockadechemoattractant cytokinechemokineclustered regularly interspaced short palindromic repeats screencohortcomputational analysescomputational analysiscomputer analysescytokinedevelopmentaldrug/agentextracellularfitnessfunctional genomicsgene functiongenome mutationgenomic alterationgenomic platformhead/neck cancerimmune check point blockadeimmune checkpoint blockadeimmune competentimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunosuppressedimprovedin vivoinnovateinnovationinnovativeinsightlung cancermachine based learningmalignancymalignant breast tumormalignant head and neck tumormouse modelmouth SCCmouth squamous cell carcinomamultiplexed imagingmurine modelnecrocytosisneoplasm/cancernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoncologic imagingoncology imagingontogenyoral cavity SCCoral squamous canceroral squamous carcinomaovarian canceroverexpressoverexpressionpancreatic malignancypersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentplasmalemmapredict responsivenesspredicting responsepreservationrecruitrefractory cancerresistance to therapyresistantresistant cancerresistant to therapyresolutionsresponseresponse to therapyresponse to treatmentselection of treatmentsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstherapeutic T-cell platformtherapeutic resistancetherapeutic responsetherapy resistanttherapy responsetherapy selectiontranscriptomicstreatment resistancetreatment responsetreatment responsivenesstreatment selectiontumortumor behaviortumor cell metastasistumor growthtumor imagingtumor microenvironment
Description preview
PROJECT SUMMARY
Tumor growth and response to therapy, particularly immunotherapy, are all highly dependent on the tumor
microenvironment (TME): the collection of cells and extracellular factors (cytokines, chemokines, collagens, etc.)
that form around cancer cells. This is evident from the major impact drugs targeting TME components can have
on…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click