grant
Spatial and Epigenetic Regulation of AAV Localization and Persistence
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 19 Apr 2026Deadline 18 Apr 2028
NIHUS FederalResearch GrantFY2026Adeno-Associated VirusesAdenoviridaeAdenovirusesAffectAssayAssociated VirusesAttenuatedAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBindingBinding SitesBioassayBioinformaticsBiological AssayBiologyCapsidCell BodyCell Communication and SignalingCell DeathCell NucleusCell SignalingCellsChIP assayChemicalsChromatinCombining SiteCommunicationDNADNA DamageDNA InjuryDNA RecombinationDNA Repair GeneDNA TherapyDNA VirusesDNA repair proteinDeoxyribonucleic AcidDependoparvovirusDependovirusDevelopmentDoseEZF proteinEducational process of instructingEnabling FactorsEngineered GeneEngineeringEnvironmentEpisomeEventFacultyFamilyFutureGKLF proteinGene ExpressionGene Therapy VectorsGene TranscriptionGene Transduction AgentGene Transduction VectorsGene Transfer ClinicalGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenetic DiseasesGenetic InterventionGenetic RecombinationGenetic TranscriptionGenomeGenomic SegmentGenomicsGoalsHPVHeadHelper VirusesHerpesviridaeHerpesvirusesHigh-Throughput Nucleotide SequencingHigh-Throughput SequencingHuman Papilloma VirusHuman PapillomavirusImageImaging technologyInfectionInfectious Human Wart VirusIntracellular Communication and SignalingKlf4 proteinKruppel-like factor 4LeadershipLiteratureMediatingMethodsMicrobiologyMolecularMolecular InteractionMolecular VirologyMonitorMutateNuclearNucleusOncogenesisOncogenic VirusesOncologyOncology CancerPARP InhibitorPARP PolymerasePARP proteinPARP-1 inhibitorPARPiPARSPapilloma VirusesPapillomaviridaePapillomavirusParvovirusPatientsPicodnavirusPoly(ADP-ribose) Polymerase InhibitorPoly(ADP-ribose) PolymerasesPoly(ADP-ribose) polymerase 1 inhibitorPoly(ADPribose) PolymeraseProcessProteinsProtoparvovirusRNA ExpressionReactive SiteRecombinantsRecombinationResearchResearch TrainingRoleSatellite VirusesSignal TransductionSignal Transduction SystemsSignalingSingle Stranded DNA VirusSiteSystemTailTeachingTechnical ExpertiseTechnologyTestingTrainingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransgenesTumor VirusesViralViral GenesViral GenomeVirusWorkadeno associated virus groupattenuateattenuatesbiological adaptation to stressbiological signal transductioncareercell transductioncellular transductionchromatin immunoprecipitationcis acting elementdesigndesigningdevelopmentaldrivingepigenetic regulationepithelial zinc finger proteinexperimentexperimental researchexperimental studyexperimentsextrachromosomal DNAgene repair therapygene therapygene-based therapygenetic conditiongenetic disordergenetic therapygenome segmentgenomic regiongenomic therapygut-enriched Kruppel-like factorherpes virusimagingimprovedinhibitorinsightmutantnanopore based sequencingnanopore long read seqnanopore long-read sequencingnanopore seqnanopore sequencingnanopore-based long-read sequencingnecrocytosisoncogenic tumor virusparvovirus grouppharmacologicpoly ADP polymerasepoly ADP ribose synthetasepromoterpromotorreaction; crisisrecruitreplication stressresponseside effectskillssocial rolessDNA Virusstress responsestress; reactiontechnical skillstherapeutic transgenetherapeutically effectivetranscription factortransduced cellstransgenetumorigenesisvectorvector genomevirologyvirus genomewart virus
Description preview
PROJECT SUMMARY/ABSTRACT
Adeno-Associated Virus type 2 (AAV2) is a single-stranded DNA virus in the Parvovirus family that is
modified to serve as a platform for recombinant AAV2 gene therapy vectors (rAAV). AAV2 depends on a
coinfecting “helper” virus (such as Adenovirus, Herpesvirus, and Papillomavirus) or exogenous DNA
damage, to replicate in…
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