grant
SORL1 and its involvement in Alzheimer's disease pathogenesis and pathophysiology - Project 2
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 15 Sept 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AD dementiaAD pathologyAD3-like proteinAD3LPAffectAllelesAllelomorphsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease pathologyAlzheimer's pathologyAlzheimers DementiaAntimorphic mutationAssayBenignBindingBioassayBiochemicalBiologicalBiological AssayC-terminalCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCURLCas nuclease technologyCause of DeathCell BodyCell surfaceCellsCellular biologyCharacteristicsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollaborationsCompartment of the Uncoupling Receptors and LigandsComplexDNA mutationDefectDestinationsDevelopmentDimerizationDiseaseDisorderDominant NegativeDominant-Negative MutantDominant-Negative MutationDysfunctionER stressER-associated degradation PathwayERADEarly EndosomeEndocytosisEndoplasmic ReticulumEndoplasmic Reticulum Degradation PathwayEndosomesEngineeringErgastoplasmFunctional disorderGene AlterationGene MutationGene variantGenesGenetic ChangeGenetic DiseasesGenetic ModelsGenetic defectGenetic mutationGliaGlial CellsGoalsGolgiGolgi ApparatusGolgi ComplexHealthHortega cellHumanIntegral Membrane ProteinIntrinsic Membrane ProteinKnowledgeKolliker's reticulumLate Onset Alzheimer DiseaseLeftMethodsMicrogliaMissense MutationModern ManMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMutateMutationNerve CellsNerve DegenerationNerve UnitNeural CellNeurocyteNeurogliaNeuroglial CellsNeuron DegenerationNeuronsNon-neuronal cellNonneuronal cellPSEN1PSEN2PathogenesisPathogenicityPathway interactionsPatientsPhenocopyPhenotypePhysiopathologyPositionPositioning AttributePreventivePrimary Senile Degenerative DementiaProtein DimerizationProtein TruncationProteinsProteomicsReceptor CellReceptor ProteinReceptosomesRecyclingResearchRisk FactorsS182 proteinSortingStructureSystemTestingTransmembrane ProteinTransmembrane Protein GeneVariantVariationVenusWorkaged brainaging brainallelic variantbiologiccausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell biologycell typeconformationconformationalconformational stateconformationallyconformationscostdata modelingdesigndesigningdevelopmentaldimerendoplasmic reticulum stressfamilial ADfamilial Alzheimerfamilial Alzheimer diseasefitnessgene defectgenetic conditiongenetic disordergenetic predictorsgenetic variantgenome mutationgenomic variantgitter cellhealthy aginghealthy human aginghiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshuman modeliPSiPSCiPSCsinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinnovateinnovationinnovativeinsightlate onset alzheimermesogliamicroglial cellmicrogliocytemissense single nucleotide polymorphismmissense single nucleotide variantmissense variantmodel of datamodel of humanmodel the datamodeling of the datamonomermouse modelmurine modelmutantmutant allelenerve cementneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronalneuronal degenerationnovelpathophysiologypathwayperivascular glial cellpresenilin 1 proteinpresenilin 2 proteinpresenilin-1presenilin-2primary degenerative dementiaprogramsreceptorresponsereticulum cellsenile dementia of the Alzheimer typetrafficking
Description preview
PROJECT 2 SUMMARY
Alzheimer’s disease (AD) is poised to become the third leading cause of death in much of the developed world,
and is the only major cause of death for which no preventive or disease-modifying treatment exists. If none is
found, AD will cost the U.S. a trillion dollars annually by 2050. About 10% of all cases of AD are genetic and…
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