grant
Somatostatin neurons and learning
Organization CARNEGIE-MELLON UNIVERSITYLocation PITTSBURGH, UNITED STATESPosted 8 Apr 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20265-HT5-Hydroxytryptamine5HTAD dementiaAcuteAffectAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnimalsAreaAssociation LearningAssociative LearningAxonBehaviorBrainBrain Nervous SystemCNS plasticityCell BodyCell Communication and SignalingCell SignalingCellsCerebral cortexCognitionCognitiveColumn of BertiniComplexConnector NeuronCortical ColumnCuesCyclic SomatostatinDataDendritesDevelopmentDiseaseDisorderDistalDopamineDysfunctionElectrophysiologyElectrophysiology (science)EncephalonEnteramineExhibitsFrustrationFunctional disorderGene TranscriptionGeneticGenetic TranscriptionGrowth Hormone Inhibiting FactorsGrowth Hormone-Inhibiting HormoneHeadHeterogeneityHippophaineHomeHydroxytyramineImageImpairmentIn VitroIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingLabelLearningLevarterenolLevonorepinephrineLinkMediatingMethodsMiceMice MammalsMolecularMonitorMorphologyMurineMusNeocortexNerve CellsNerve UnitNeural CellNeurocyteNeuromodulatorNeuronal PlasticityNeuronsNeurophysiology / ElectrophysiologyNoradrenalineNorepinephrineOutcomePathway interactionsPavlovian conditioningPerceptionPhysiopathologyPopulationPrimary Senile Degenerative DementiaPropertyPsychological reinforcementPyramidal neuronRNA ExpressionRegulationReinforcementRenal Column of BertiniRewardsRoleSRIHSRIH-14SchizophreniaSchizophrenic DisordersSensorimotor functionsSensorySerotoninSignal TransductionSignal Transduction SystemsSignalingSliceSomatostatinSomatostatin-14Somatotropin Release Inhibiting FactorsSomatotropin Release-Inhibiting HormoneSourceStimulusSynapsesSynapticSystemTestingTimeTrainingTranscriptionVibrissaeViralWhiskersassociative conditioningbarrel cortexbiological signal transductioncell typecentral nervous system plasticityclassical conditioningdementia praecoxdevelopmentalelectrophysiologicalexpectationexperiencegrowth hormone release inhibiting factorhippocampal pyramidal neuronhomeshomotypical corteximagingimaging in vivoimaging studyin vivoin vivo imaginginformation processinginhibitory neuroninsightisocortexneocorticalneopalliumneural circuitneural circuitryneural controlneural plasticityneural regulationneurocircuitryneuromodulationneuromodulatoryneuronalneuroplasticneuroplasticityneuroregulationoperationoperationsoptogeneticspatch clamppathophysiologypathwayperceptual stimulusphysicochemical phenomena related to the sensesprimary degenerative dementiaresponseschizophrenicsenile dementia of the Alzheimer typesensory cortexsensory inputsensory stimulussocial rolesomatosensorysynapsesynaptic circuitsynaptic circuitrytissue fixingtranscriptomics
Description preview
ABSTRACT ___________
Somatostatin-expressing (SST) GABAergic neurons are a key component of neocortical circuits, implicated in
sensory perception, plasticity, and disease. Understanding SST function has been hampered by the diverse
transcriptional and electrophysiological profiles of this inhibitory neuronal class, with between 10 and nearly 40…
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