grant
Sodium in the Skin and Atopic Dermatitis: The SIS-AD Study
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 22 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AddressAffectAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAgeAreaAtopic DermatitisAtopic EczemaAtopic NeurodermatitisBiological MarkersBlack PopulationsBlack groupBlack individualBlack peopleBlacksBloodBlood Reticuloendothelial SystemBody TissuesCardiovascular DiseasesCell BodyCellsCellular Immune FunctionChronicChronic DiseaseChronic IllnessClinical ResearchClinical StudyClinical TrialsCohort StudiesConcurrent StudiesConsumptionCutaneous DisorderCutaneous imagingCytometryDermatologic biopsyDermatological ImagingDermatosesDevelopmentDietDietary FactorsDietary SodiumDietary Sodium ChlorideDiseaseDisorderDisseminated NeurodermatitisEczemaEczematous DermatitisEnrollmentEnvironmental FactorEnvironmental Risk FactorEpidemiologic ResearchEpidemiologic StudiesEpidemiologic trendEpidemiological StudiesEpidemiological trendEpidemiologyEpidemiology ResearchEpidemiology trendFood frequency questionnaireFutureGoalsHeterogeneityHydrationHydration statusHydrogen OxideHypertensionImageImaging ProceduresImaging TechnicsImaging TechniquesImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune Modulation TherapyImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunesImmunologic DiseasesImmunologic StimulationImmunological DiseasesImmunological DysfunctionImmunological StimulationImmunological System DysfunctionImmunologyImmunostimulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIndustrializationInflammationInflammatoryIntakeInterventionInvestigatorsItchingLaboratoriesLinkLong-term cohort studyLongitudinal cohort studyMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceModelingNMR ImagingNMR TomographyNa elementNuclear Magnetic Resonance ImagingOrganParticipantPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPersonsPhenotypePhysiologicPhysiologicalPhysiologyPopulationProcessProteinsProteomicsPruritic DisorderPruritisPruritusQOLQuality of lifeR-Series Research ProjectsR01 MechanismR01 ProgramResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersRoleSeveritiesSkinSkin DiseasesSkin Diseases and ManifestationsSkin ImagingSodiumSodium ChlorideSubgroupTable SaltTechniquesTestingTh-2 CellTh2 CellsTimeTissuesTranslational ResearchTranslational ScienceType 2 Helper CellUrineVariantVariationVascular Hypertensive DiseaseVascular Hypertensive DisorderVisitWaterWaxesWomanWorkZeugmatographyagedagesallergic dermatitisallergic eczemaaptamerbio-markersbiologic markerbiomarkerburden of diseaseburden of illnesscardiovascular disease epidemiologycardiovascular disordercardiovascular disorder epidemiologycardiovascular epidemiologychronic disorderclinical phenotypecohortcutaneous barriercutaneous biopsycutaneous diseasecutaneous lesionsdermal barrierdermal diseasedermal disorderdermal lesiondesigndesigningdevelopmentaldietarydietary Nadietary excessdietary saltdietsdisease burdeneconomic impacteczematousenrollenvironmental changeenvironmental riskepidemiologicepidemiologic investigationepidemiologicalepidemiology studyepidermal barrierexperiencehigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimagingimmune functionimmune modulatory therapiesimmune modulatory treatmentimmune regulation therapyimmune regulation treatmentimmune regulatory therapyimmune suppressionimmune suppressive activityimmune suppressive functionimmune-modulation treatmentimmunomodulation therapyimmunomodulation treatmentimmunomodulator therapiesimmunomodulator treatmentimmunomodulator-based therapiesimmunomodulatory biologicsimmunomodulatory therapiesimmunomodulatory treatmentimmunoregulatory therapyimmunoregulatory treatmentimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedinnovateinnovationinnovativeitch sensationlife-style factorlifestyle factorsmenmultidisciplinarynatural agingnew approachesnormal agingnormative agingnovelnovel approachesnovel strategiesnovel strategynutritional epidemiologyolder adultolder adulthoodpathwaypatient oriented outcomespreservationpreventpreventingrecruitresponseresponse to therapyresponse to treatmentsaltsalt intakesalt sensitiveskin barrierskin biopsyskin disorderskin lesionsocial rolesystemic inflammationsystemic inflammatory responsetherapeutic immunomodulationtherapeutic immunoregulationtherapeutic responsetherapy responsetranslation researchtranslational investigationtreatment responsetreatment responsiveness
Description preview
ABSTRACT
Atopic dermatitis (AD) rates have tripled since the 1950s, and are highest in urban and industrialized areas,
likely due to changing environmental and dietary factors. Atopic dermatitis is now the most burdensome skin
disease globally, and disease course and response to new immunomodulatory treatments remain highly
variable. There is a…
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