grant
Social environment determines the hedonice value of nicotine via molecular and cellular networks in the amygdala
Organization UNIVERSITY OF TENNESSEE HEALTH SCI CTRLocation MEMPHIS, UNITED STATESPosted 15 Jul 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY202612-20 years old4-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAdministratorAdolescenceAdolescentAdolescent YouthAffectAminalonAminaloneAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAttenuatedBathingBathsBehaviorBehavioralBindingBrainBrain Nervous SystemBrain regionCa(v)1.2 channelCav1.2 calcium channelCell Communication and SignalingCell SignalingCessation of lifeCommon Rat StrainsCompanionsConsumptionCuesDataDeathDiseaseDisorderElectrophysiologyElectrophysiology (science)EncephalonExposure toExtinctionFiberGABAGWA studyGWASGenesHealth PolicyHeterozygoteHumanHypothalamic structureHypothalamusImmediate-Early GenesInfusionInfusion proceduresInjectionsIntakeIntracellular Communication and SignalingIntravenousKnock-outKnockoutL-type calcium channel alpha(1C)LearningMediatingMessenger RNAModelingModern ManMolecularMolecular InteractionMonitorNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNicotineNicotine DependenceOcytocinOralOxytocinOxytocin ReceptorPathway interactionsPhotometryPlayProcessPropertyProteinsPublic HealthQuinineRatRats MammalsRattusRecombinant OxytocinResearchRewardsRodentRodentiaRodents MammalsRoleRouteScheduleSelf AdministeredSelf AdministrationSignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingSmokingSocial BehaviorSocial EnvironmentSocial InteractionSubstance Use DisorderTestingUnited StatesVisualizationWorkabused drugabused drugsadolescence (12-20)alpha(1C) channelalpha1C calcium channelamygdaloid nuclear complexantagonismantagonistattenuateattenuatesbiological signal transductioncausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell typedrug abuseddrug of abusedrugs abuseddrugs of abuseelectrophysiologicalexperienceexposure to nicotinegamma-Aminobutyric Acidgenetic associationgenome editinggenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic editingglobal gene expressionglobal transcription profilehealth care policyhedonicheterozygosityhypothalamicinfusionsinsightjuvenilejuvenile humanmRNAmultidisciplinaryneuralneural mechanismneuromechanismneuronalnicotine addictionnicotine consumptionnicotine dependentnicotine exposurenicotine self-administrationnicotine usenon-smokernonsmokernoveloptogeneticspatch clamppathwaypreventpreventingreal time monitoringrealtime monitoringresponsesNuc-Seqsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsmoking initiationsnRNA sequencingsnRNA-seqsocialsocial climatesocial contextsocial factorssocial influencesocial learningsocial rolesociobehaviorsociobehavioralsocioenvironmentsocioenvironmentalsubstance use and disordertranscriptometranscriptomicswhole genome association analysiswhole genome association studyγ-Aminobutyric Acid
Description preview
Nicotine addiction is a major public health concern, causing over 480,000 deaths annually in the United States.
Despite its addictive properties, initial nicotine exposure in nonsmokers is usually aversive. The initiation of
smoking is heavily influenced by social factors, particularly during adolescence. We developed a rat model,
Socially…
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