grant
Smooth Muscle Mechanotransduction: Calcium Dynamics in the Developing Gut
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult HumanAgeAilmentary SystemAlimentary SystemAutomobile DrivingAutoregulationCalciumCause of DeathCell BodyCell Communication and SignalingCell SignalingCell membraneCellsCellular MechanotransductionComplicationCoupledCuesCytoplasmic MembraneDataDevelopmentDevelopmental ProcessDigestive SystemDoctor of MedicineEXTMREnvironmentExtramuralExtramural ActivitiesFoundationsFundingGastroenterologyGastrointestinal Body SystemGastrointestinal MotilityGastrointestinal Organ SystemGoalsGut EpitheliumHomeostasisImageImpairmentIn SituIn VitroInfantIntestinalIntestinal MotilityIntestinesIntracellular Communication and SignalingInvoluntary MuscleIon ChannelIonic ChannelsKnowledgeLeadLeiomyocyteLifeM.D.MaintenanceMechanical Signal TransductionMechanicsMechanosensory TransductionMeconiumMedicineMembrane ChannelsMentorsMentorshipMiceMice MammalsMissionModelingMurineMusNIDDKNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthNecrotizing EnterocolitisNeonatalObstructionOrganOrganism-Level ProcessOrganismal ProcessPathway interactionsPb elementPeristalsisPhysiciansPhysiologic ProcessesPhysiological HomeostasisPhysiological ProcessesPiezo 1Piezo 1 ion channelPiezo1Plasma MembranePlayProcessRegulationResearchRiskRoleSarcoplasmic ReticulumScientistSerotonin ProductionShort Bowel SyndromeSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSmooth MuscleSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSpatial DistributionStrategic PlanningStretchingTechniquesTechnologyTestingTherapeuticTimeTrainingUnited StatesUnited States National Institutes of Healthadulthoodage associatedage correlatedage dependentage linkedage relatedage specificagesbiological signal transductionbowelclinical relevanceclinically relevantconditional knock-outconditional knockoutdesigndesigningdevelopmentaldisabilitydrivingdysmotilitydysmotility syndromeeffective therapyeffective treatmentexperimentexperimental researchexperimental studyexperimentsfeedingforginggastrointestinalgastrointestinal epitheliumgastrointestinal functiongastrointestinal systemheavy metal Pbheavy metal leadimagingimprovedimproved outcomein vivoinnovateinnovationinnovativeinsightintestinal maturationmechanicmechanicalmechanosensingmechanotransductionmotility disordermouse modelmurine modelneonatal periodneonatepathwayplasmalemmapost-natal periodpostnatal periodprematureprematurityprogramsshort gut syndromesocial rolesuperresolution microscopytherapeutic targettool
Description preview
PROJECT SUMMARY/ABSTRACT
This NIH Mentored Clinician Scientist Development (K08) proposal describes a comprehensive 5-
year training plan designed to establish Geoanna Bautista, M.D. as an independent physician-
scientist focused on mechanosensitive signaling pathways that contribute to neonatal intestinal
dysmotility. Prematurity is the leading…
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