grant
Smart Laser Capturing Microscope for Genome Wide Single Cell Spatial Transcriptomics
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 8 Jan 2025Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026AI AugmentedAI assistedAI basedAI drivenAI enhancedAI integratedAI poweredATAC sequencingATAC-seqATACseqArtificial Intelligence enhancedAssay for Transposase-Accessible Chromatin using sequencingAugmented by AIAugmented by the AIAugmented with AIAugmented with the AIBar CodesBiologyBody TissuesCancersCell BodyCell IsolationCell SegregationCell SeparationCell Separation TechnologyCellsCellular AssayChromiumCompetenceComplexCr elementDNADNA seqDNA sequencingDNAseqDataDeoxyribonucleic AcidDiseaseDisorderDissociationEnsureEnvironmentFaceFluorescence Light MicroscopyFluorescence MicroscopyGenerationsGeneticGenetic MaterialsGenomicsHealthImageImage AnalysesImage AnalysisIn SituIndividualLabelLaser ElectromagneticLaser RadiationLasersLinkLocationMalignant NeoplasmsMalignant TumorMapsMethodologyMethodsMethylationMicroscopeMicroscopyMolecularNGS MethodNGS systemNon-Polyadenylated RNAOpticsOrganismOutcomePathway interactionsProcessProtocolProtocols documentationRNARNA Gene ProductsReadabilityResearchResolutionRibonucleic AcidSamplingSingle cell seqSlideSpeedStructureSystemTechniquesTechnologyTissue SampleTissuesTranscendartificial intelligence assistedartificial intelligence augmentedartificial intelligence basedartificial intelligence drivenartificial intelligence integratedartificial intelligence poweredassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbarcodecell assaycell sortingdesigndesigningenhanced with AIenhanced with Artificial Intelligenceexperiencefacesfacialfeature detectionfeature recognitionforginggenome scalegenome-widegenomewidegenomic datagenomic datasethigh definitionhigh-resolutionimage evaluationimage interpretationimagingimprovedinnovateinnovationinnovativeinsightlaser capture microdissectionlife spanlifespanliving systemmalignancymicroscope imagingmicroscopic imagingmicroscopy imagingmultiomicsmultiple omicsnanoneoplasm/cancerneural networknew approachesnext gen sequencingnext generation sequencingnextgen sequencingnovelnovel approachesnovel strategiesnovel strategyopticalpanomicspathwayresolutionsscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell analysissingle cell expression profilingsingle cell next generation sequencingsingle cell sequencingsingle cell transcriptomic profilingsingle-cell RNA sequencingspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial integrationspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstooltranscriptomics
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PROJECT SUMMARY
We introduce an innovative AI-Assisted Laser Capture Microdissection (AI-LCM) approach for Spatial
Transcriptomics, designed to overcome the limitations of existing spatial biology methods. Current techniques
like MERFISH, Visium, and traditional LCM have distinct strengths, but they fall short in providing both single-
cell…
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