grant
Small Research Grant Program for the Next Generation of Researchersin AD/ADRD Research
Organization HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCESLocation EAST LANSING, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20262-photonAD and related dementiaAD dementiaAD modelAD patientsAD related dementiaADRDAchievementAchievement AttainmentAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's Disease and its related dementiasAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease modelAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease patientAlzheimer's disease related dementiaAlzheimer's patientAlzheimers DementiaAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAnimal DiseasesAnimal ModelAnimal Models and Related StudiesAβBiologicalBiological MarkersBloodBlood Reticuloendothelial SystemBlood VesselsBrainBrain Nervous SystemBrain imagingCNS lymphatic systemCerebrospinal FluidCerebrovascular systemCerebrumClinicClinical ResearchClinical StudyCommon Rat StrainsContrast AgentContrast DrugsContrast MediaCoupledDangerousnessDataDegenerative Neurologic DisordersDetectionDevelopmentDiseaseDisease OutcomeDisease ProgressionDisorderEncephalonFe oxideGadoliniumGd elementImageImaging ProceduresImaging TechnicsImaging TechniquesImmuneImmunesImpairmentIndividualInjectionsIntercellular FluidInterstitial FluidsInvestigationMR ImagingMR TomographyMRIMRI biomarkerMRI markerMRIsMagnetic Resonance ImagingMapsMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsModelingMolecularNMR ImagingNMR TomographyNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurologic DisordersNeurological DisordersNuclear Magnetic Resonance ImagingOutcomePathway interactionsPatientsPlayPredispositionPrimary Senile Degenerative DementiaR-Series Research ProjectsR01 MechanismR01 ProgramRadiopaque MediaRatRats MammalsRattusResearchResearch GrantsResearch Project GrantsResearch ProjectsRoleSeverity of illnessSusceptibilitySystemTechniquesTestingTherapeutic InterventionVascular SystemZeugmatographya beta peptideabetaabeta depositionalzheimer modelamyloid betaamyloid beta depositionamyloid β depositionamyloid-b proteinaβ depositionbeta amyloid fibrilbio-markersbiologicbiologic markerbiomarkerblood vessels in the brainbrain blood vesselsbrain lymph systembrain lymphatic systembrain microvasculaturebrain microvesselsbrain parenchymabrain vasculaturebrain visualizationcerebralcerebral blood vesselcerebral microvasculaturecerebral microvesselscerebral spinal fluidcerebral vasculaturecerebrovascular vesselscerebrovasculaturecolcothardegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdetection sensitivitydevelopmentaldisease severityextracellularferric oxidefluorescence imagingfluorescent imagingglia lymphatic circuitglia-lymphatic systemglial lymphatic systemglialymphatic circuitglialymphatic networkglialymphatic pathwayglialymphatic systemglymphatic clearance pathwayglymphatic pathwayglymphatic systemglymphatic-lymphatic systemglymphaticsimage-based methodimagingimaging approachimaging based approachimaging methodimaging modalityimprovedinsightintervention therapyiron oxidemagnetic resonance imaging biomarkermagnetic resonance imaging markermodel of animalneurodegenerative illnessneurological diseasenew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynext generationnovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachparavascular systempathwaypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepatients with ADprimary degenerative dementiaprogramsred iron oxideresponsesenile dementia of the Alzheimer typesocial rolesoluble amyloid precursor proteinspinal fluidsuperparamagneticsuperparamagnetismtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttwo-photonvascularvascular componentvascular contributionsvascular factorwastingweighted imaging
Description preview
Project Summary
The objectives of this proposal are to optimize and validate detection and modeling of the multicomponent
vascular and glymphatic systems in cerebral waste clearance (CWC) using superparamagnetic iron oxide
(SPIO)-enhanced susceptibility weighted imaging (SWI, SPIO-SWI), and then to investigate CWC in the vascular
and glymphatic…
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