grant
Small Molecule Protease Inhibitors against MERS-CoV and Coronaviruses of Pandemic Potential
Organization KANSAS STATE UNIVERSITYLocation MANHATTAN, UNITED STATESPosted 19 Jul 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAnti-viral AgentsAntiproteasesAssayBatsBindingBioassayBioavailabilityBiochemicalBiological AssayBiological AvailabilityCOVID-19 virusCOVID19 virusCategory C pathogenCategory C priority pathogenCell BodyCell Culture TechniquesCellsCellular AssayCharacteristicsChemicalsChiropteraCoV emergenceCoV-2CoV2CoronaviridaeCoronaviridae InfectionsCoronavirusCoronavirus InfectionsCrystallographiesCrystallographyDeath RateDevelopmentDiseaseDisease OutbreaksDisorderDoseDrug resistanceDrugsEndopeptidase InhibitorsEndowmentEnzyme GeneEnzymesEsteroproteasesEvaluationFDA approvedFundingFutureGoalsHCoVHumanIn VitroLeadLytotoxicityMERSMERS corona virusMERS coronavirusMERS coronavirus diseaseMERS virusMERS-CoVMERS-CoV diseaseMedicationMerbecovirusMiddle EastMiddle East Respiratory SyndromeMiddle East Respiratory Syndrome CoV diseaseMiddle East Respiratory Syndrome Corona VirusMiddle East Respiratory Syndrome CoronavirusMiddle East Respiratory Syndrome VirusMiddle East Respiratory Syndrome coronavirus diseaseMiddle East Respiratory Syndrome-CoVMiddle East Respiratory VirusMiddle East Respiratory coronavirusMiddle Eastern Respiratory SyndromeMiddle Eastern Respiratory Syndrome CoV diseaseMiddle Eastern Respiratory Syndrome Corona virusMiddle Eastern Respiratory Syndrome CoronavirusMiddle Eastern Respiratory Syndrome VirusMiddle Eastern Respiratory Syndrome coronavirus diseaseMiddle Eastern Respiratory Syndrome-CoVModern ManMolecular InteractionNIAIDNational Institute of Allergy and Infectious DiseaseOralOrthocoronavirinaeOutbreaksPb elementPeptidase InhibitorsPeptidasesPeptide Hydrolase InhibitorsPeptide HydrolasesPeptide Peptidohydrolase InhibitorsPharmaceutical PreparationsPhysiologic AvailabilityPolyproteinsProcessPropertyProtease AntagonistsProtease GeneProtease InhibitorProteasesProteinase InhibitorsProteinasesProteolytic EnzymesPublic HealthReceptor ProteinReporterReportingRepublic of KoreaResearchSARS VirusSARS corona virusSARS corona virus 2SARS coronavirusSARS-Associated CoronavirusSARS-CO-V2SARS-COVID-2SARS-CoVSARS-CoV-1SARS-CoV-2SARS-CoV2SARS-Related CoronavirusSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SarbecovirusSaudi ArabiaSeriesSevere Acute Respiratory CoronavirusSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome VirusSevere Acute Respiratory Syndrome corona virusSevere Acute Respiratory Syndrome coronavirusSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2SiteSouth KoreaStructureStructure-Activity RelationshipVaccinesViralVirusVirus ReplicationWorld Health OrganizationWuhan coronavirusanaloganti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsbeta CoVbeta coronavirusbetaCoVbetacoronaviruscell assaycell culturecell cultureschemical structure functioncorona viruscorona virus emergencecoronavirus disease 2019 viruscoronavirus disease-19 viruscoronavirus emergencecoronavirus of pandemic concerncoronavirus of pandemic potentialcoronavirus with pandemic potentialcytotoxicitydesigndesigningdevelopmentaldrug resistantdrug/agentemergent CoVemergent corona virusemergent coronavirusemerging CoVemerging corona virusemerging coronavirusfuture pandemichCoV19heavy metal Pbheavy metal leadhigh riskhuman CoVhuman corona virushuman coronavirusimprovedin vivoindexinginhibitormembermetermortality ratemortality ratiomouse modelmurine modelnCoVnCoV2new CoVnew corona virusnew coronavirusnext pandemicnovelnovel CoVnovel corona virusnovel coronaviruspandemic coronaviruspandemic threat coronaviruspharmacologicpre-clinicalpreclinicalpublic health emergencyreceptorresistance to Drugresistant to Drugrespiratoryscaffoldscaffoldingscreeningscreeningssevere acute respiratory syndrome-CoVsmall moleculestructural determinantsstructural factorsstructure function relationshipsynergismtherapeutic targetviral multiplicationviral replicationvirus multiplicationβ CoVβ coronavirusβCoV
Description preview
PROJECT SUMMARY
Middle East respiratory syndrome coronavirus (MERS-CoV) emerged suddenly in 2012 as the cause of
severe respiratory illness in humans. Despite the high mortality rate (~ 40%) and the significant potential for a
public health emergency, there are no FDA-approved vaccines or antiviral drugs for MERS. Consequently, there
is an urgent…
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