grant
Skeletal Muscle Fibrosis and Progesterone Receptor
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AROARO1ATACATAC sequencingATAC-seqATACseqAbdominal HerniaAbdominal MusclesAblationAcetatesAdjuvant TherapyAffectAgingAnatomic SitesAnatomic structuresAnatomyAndrostenedione Aromatase InhibitorAnti-EstrogensAquadiolAreaAromataseAromatase InhibitorsAssay for Transposase-Accessible Chromatin using sequencingAtrophicAtrophyBioinformaticsBiopsyBloodBlood Reticuloendothelial SystemBody TissuesCD140a AntigensCPV1CYARCYP 19CYP19CYP19A1CYP19A1 geneCell NucleusCell-Extracellular MatrixChIP SequencingChIP-seqChIPseqCharacteristicsCorlutinaCorluviteCorpus Luteum HormoneCyclogestCytochrome P-450 CYP19Cytochrome P450 19Cytochrome P450 19A1DataDelta4-pregnene-3,20-dioneDevelopmentDimenformonDiogynDiogynetsDiseaseDisorderECMElderly manEnzyme GeneEnzymesEstraceEstradiolEstradiol-17 betaEstradiol-17betaEstraldineEstrogen AntagonistsEstrogen ReceptorsEstrogen SynthaseEstrogen Synthase InhibitorEstrogen SynthetaseEstrogen Synthetase InhibitorExtracellular MatrixFibroblastsFibrosisGene ExpressionGenesGeneticGenomicsGestagenic AgentsGestagensGestironGestoneHerniaHernia of abdominal cavityHistologicHistologicallyHumanImmunoblottingImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIncidenceInfectionInguinal HerniaIntervention StrategiesKnock-outKnockoutLPTNLabelLeadLinkLipo-LutinLuteohormoneLutocyclinLutocylin MLutogylLutromoneMeasuresMediatingMediatorMessenger RNAMiceMice MammalsMifegyneMifeprexMifepristoneModelingModern ManMolecularMurineMusMuscleMuscle AtrophyMuscle CellsMuscle TissueMuscle WeaknessMuscular AtrophyMuscular WeaknessMyocytesNucleusOperative ProceduresOperative Surgical ProceduresOsteoporosisOvocyclinOvocylinP-450AROMP450AROMPDGF alpha ReceptorPDGF receptor αPDGF-R-alphaPDGFR-αPDGFRαPathway interactionsPb elementPhenotypePlatelet-Derived Growth Factor Receptor Alpha PolypeptidePlatelet-Derived Growth Factor alpha ReceptorPost-operative PainPostoperative PainPregn-4-ene-3,20-dionePregnenedionePreventiveProcessProgestagenic AgentsProgestasertProgestational AgentsProgestational CompoundsProgestational HormonesProgesteroneProgesterone AgentsProgesterone ReceptorsProgestin ReceptorsProgestinsProgestogelProgestogensProgestolProgestonProgynonProlidonProliferatingProlutonProteinsR 38486R 5020R38486R5020RNA SeqRNA sequencingRNAseqRU-38486RU-486RU-5020RU38486RU486RU5020Receptor ProteinReceptor SignalingRecurrenceRecurrentRefractoryRoleSCM-1SCM-1aSCM1SCYC1Sex DisordersSexual DysfunctionShort interfering RNASkeletal MuscleSmall Interfering RNASurgeonSurgicalSurgical InterventionsSurgical ProcedureSyngesteroneTestingTestosteroneTherapeuticTherapeutic EstradiolTherapeutic ProgesteroneTherapeutic ProgestinTherapeutic TestosteroneTissuesTrans-TestosteroneUtrogestanVoluntary MuscleWestern BlottingWestern ImmunoblottingWild Type MouseXCL1XCL1 geneadjuvant treatmentantagonismantagonistantiestrogenantiestrogenicassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingclinical relevanceclinically relevantconditional knock-outconditional knockoutdevelopmentalelderly menepigenomicsestrogen inhibitorestrogen receptor proteinestrophileestrophilingene signaturesgenetic signatureheavy metal Pbheavy metal leadhigh risk grouphigh risk individualhigh risk peoplehigh risk populationhormonal signalshormone signalshuman diseasehuman tissuein vivoknock-downknockdownmRNAmalemenmorphometrymouse modelmultiomicsmultiple omicsmurine modelmuscle breakdownmuscle degradationmuscle deteriorationmuscle lossmuscle wastingmuscularnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpain after surgerypanomicspathwayplatelet-derived growth factor receptor αpost-surgical painpostsurgical painpreventpreventingprotein blottingreceptorreceptor expressionrepairrepairedscRNA sequencingscRNA-seqsiRNAside effectsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesurgerytherapeutic agent developmenttherapeutic developmenttranscriptome sequencingtranscriptomic sequencingtreatment effectwildtype mouse♂
Description preview
SUMMARY
Inguinal hernia is highly prevalent, occurring in more than 1 in 4 elderly men; inguinal hernia repair is among the
most frequently performed surgeries in the US. In male mice that express the human aromatase enzyme
(Aromhum), we previously found that increased conversion of testosterone to estradiol (E2) via aromatase and
increased E2…
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