grant
Single molecule resolution imaging of stressed DNA - the next paradigm shift in cancer therapy design?
Organization UKRILocation United Kingdom
UKRIUK ResearchGrantActive
Description preview
Background: Changes in genomic stability, DNA replication, DNA damage and repair underpin carcinogenesis. Over the last 15 years the Bryant lab has pioneered targeting the DNA damage response (DDR) in cancer. This has caused a shift in precision medicine (e.g. PARP inhibitors), whilst drugs that alter replication (e.g. topoisomerase inhibitors)…
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