grant
Single molecule functional validation of neurogenomic alterations in opioid-exposed HIV brain
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 15 Feb 2026Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY202630 nm Chromatin Fiber30 nm FiberAIDS VirusATACATAC sequencingATAC-seqATACseqAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAnteriorAnti-HIV PositivityAnti-Retroviral AgentsAssayAssay for Transposase-Accessible Chromatin using sequencingAstrocytesAstrocytusAstrogliaAutopsyBasal Transcription FactorBasal transcription factor genesBase PairingBioassayBiological AssayBrainBrain Nervous SystemCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCase-Comparison StudiesCase-Compeer StudiesCase-Referent StudiesCase-Referrent StudiesCase/Control StudiesCell BodyCell Culture TechniquesCellsChromatinChromatin FiberClustered Regularly Interspaced Short Palindromic Repeats interferenceDNADataDeoxyribonucleic AcidDiseaseDisorderDrugsEncephalonEnhancersEnvironmentExposure toFiberFosteringFrequenciesGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenomicsGoalsGrantHIVHIV InfectionsHIV PositiveHIV PositivityHIV SeroconversionHIV SeropositivityHIV antibody positiveHIV disease transmissionHIV in patientsHIV infection spreadHIV infection transmissionHIV patientHIV positive patientHIV replicationHIV spreadHIV transmissionHIV viral infectionHIV viral replicationHIV viral transmissionHIV virus infectionHIV+HIV-1 infectionHIV-1 replicationHIV-1 spreadHIV-1 transmissionHIV-1 viral replicationHIV-1 virus replicationHIV-1 virus transmissionHIV/AIDS transmissionHTLV-III SeroconversionHTLV-III SeropositivityHistonesHortega cellHuman Immunodeficiency Virus Type 1 transmissionHuman Immunodeficiency VirusesHuman immunodeficiency virus infected patientsHuman immunodeficiency virus positive patientsIndividualInduced pluripotent stem cell derived human neuronInfection by HIV-1Infection from HIV-1Infection of HIV-1InflammatoryInvestigatorsLAV-HTLV-IIILPTNLibrariesLineage TracingLymphadenopathy-Associated VirusMapsMediatingMedicationMethylationMicrogliaModelingMolecularNerve CellsNerve UnitNeural CellNeurocyteNeuronsNon-Polyadenylated RNANucleosomesOpiatesOpioidPathologyPathway interactionsPatients living with HIVPatients suffering from HIVPharmaceutical PreparationsPhasePositionPositioning AttributeProtocolProtocols documentationPublishingRNARNA Gene ProductsRegulatory ElementRepressionResearch PersonnelResearchersResolutionRibonucleic AcidRiskSCM-1SCM-1aSCM1SCYC1Single ParentSingle-Nucleus SequencingSiteSubstance Use DisorderSystemTechniquesTranscription Factor Proto-OncogeneTranscription Initiation SiteTranscription Start SiteTranscription factor genesValidationViralViral DiseasesVirusVirus DiseasesVirus IntegrationVirus-HIVWorkXCL1XCL1 geneanti-retroviralassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingastrocytic gliabrain controlcase-control surveycase-controlled studiescell culturecell culturescell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingcingulate cortexco-morbidco-morbiditycohortcomorbiditycytotoxicdesigndesigningdrug/agentepigenome editingepigenomic editingfunctional genomicsgenome scalegenome-widegenomewidegitter cellglobal gene expressionglobal transcription profilehiPSC-derived neuronshuman diseasehuman iPSC-derived sensory neuronhuman immunodeficiency virus infectionhuman immunodeficiency virus patienthuman immunodeficiency virus replicationhuman immunodeficiency virus transmissionhuman immunodeficiency virus-1 replicationhuman induced pluripotent stem cell derived sensory neuronhuman tissueiPSC-derived human neuroninducible pluripotent stem cell derived human neuroninducible pluripotent stem cell derived human sensory neuroninfected with HIVinfected with human immunodeficiency virusinnovateinnovationinnovativeinsightmembermesogliamicroglial cellmicrogliocytemultiomicsmultiple omicsnecropsyneural inflammationneurogenomicsneuroinflammationneuroinflammatoryneuronalneurons differentiated from human induced pluripotent stem cellsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyopiate consumptionopiate drug useopiate exposureopiate intakeopiate useopiate use disorderopioid consumptionopioid drug useopioid exposureopioid intakeopioid useopioid use disorderpanomicspathwaypatient infected with HIVpatient with HIVperivascular glial cellpermissivenesspostmortempromoterpromotorrepressing CRISPR-dCas9 systemresolutionsresponsesNuc-SeqscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell genomicssingle cell transcriptomic profilingsingle moleculesingle nucleus RNA-sequencingsingle nucleus seqsingle-cell RNA sequencingsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqspread of human immunodeficiency virussubstance use and disordertherapeutic agent developmenttherapeutic developmenttooltranscription factortranscriptometranscriptomicsvalidationsviral genome integrationviral infectionviral integrationvirus genome integrationvirus infectionvirus-induced disease
Description preview
Neurogenomic studies by the SCORCH (Single Cell Opioid Response in the Context of HIV) consortium
strongly suggest that brains of individuals living with HIV in the context of opioid or (polys)substance use
disorder (OUD/SUD) comorbidity harbor a molecular environment permissive for HIV viral replication and risk
for cytotoxic damage. This…
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