grant
Single Molecule Detection of L1 Insertions and Intermediates
Organization DANA-FARBER CANCER INSTLocation BOSTON, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20253' Flanking Region3' Flanking SequenceAdmixtureAssayBenchmarkingBest Practice AnalysisBioassayBiological AssayBiologyBody TissuesCancersCatalogingCatalogsCell BodyCell NucleusCellsCellular AssayCodeCoding SystemComplementComplement ProteinsComplementary DNACoupledDNADNA Insertion ElementsDNA Molecular BiologyDNA Transposable ElementsDataData AnalysesData AnalysisDeoxyribonucleic AcidDetectionDevelopmentDiseaseDisorderElementsEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventGene FrequencyGene variantGenetic DiversityGenetic VariationGenomeGenomic DNAGenomicsGoalsHereditaryHeritabilityHigh-Throughput Nucleotide SequencingHigh-Throughput SequencingHumanHuman GeneticsHybridsIn SituInheritedInvestigatorsLaboratoriesLong Interspersed ElementsMalignant NeoplasmsMalignant TumorMapsMethodsMethylationModern ManMolecular BiologyMolecular ComputationsMosaicismNon-Polyadenylated RNANormal TissueNormal tissue morphologyNucleusPhasePopulationProceduresProductionProteinsQuality ControlRNARNA Gene ProductsReactionRepressionResearch PersonnelResearchersRetrotranspositionRetrotransposonReverse TranscriptionRibonucleic AcidSensitivity and SpecificitySingle Base PolymorphismSingle Nucleotide PolymorphismSiteSmaHTSomatic Mosaicism across Human TissuesSomatic MutationSortingSourceStandardizationTechnologyTissuesTn-seqTnseqTransposable ElementsValidationallelic frequencyallelic variantbenchmarkcDNAcatalogcell assaycomplementationcomputational pipelinesdata analysis pipelinedata interpretationdata processing pipelinedevelopmentalentire genomeepigeneticallyexperiencefull genomegDNAgene locusgenetic locusgenetic variantgenome scalegenome-widegenomewidegenomic locationgenomic locusgenomic toolsgenomic varianthuman tissueinnovateinnovationinnovativeinsertion elementinsertion sequenceinstrumentlong read seqlong-read sequencinglong-read transcript sequencingmalignancymethod developmentmosaic diseasesmosaic disordersmultidisciplinarynano porenanoporeneoplasm/cancerpromoterpromotorscale upsingle cell technologysingle moleculesingle nucleotide variantsomatic variantstructural mutationstructural variantstructural variationtech developmenttechnology developmenttooltool developmenttransposon insertion sequencingtransposon sequencingvalidationsvariant detectionwhole genome
Description preview
Project Summary
Transposable elements are major sources of heritable human genetic variation and can contribute to disease by
causing somatic mutations. This application focuses on the development of genomic tools and technologies to
assess the contributions of these transposons to somatic mosaicism in normal tissues. Specifically, we will
develop…
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