grant
Single-Cell Molecular Pathway Analysis in Aging Systems via Novel Mass Cytometry Methods
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Jun 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2026AgingAntibodiesAssayAutophagocytosisAutoregulationBar CodesBioassayBiological AgingBiological AssayBiological FunctionBiological MonitoringBiological ProcessBiotechBiotechnologyBody TissuesCell AgingCell BodyCell SenescenceCell SurvivalCell ViabilityCellsCellular AgingCellular SenescenceCharacteristicsClosure by LigationCytometryDNADeoxyribonucleic AcidDetectionDevelopmentDiseaseDisorderFoundationsFutureGoalsHeterogeneityHomeostasisHuman FigureHuman bodyImageIndividualIntermediary MetabolismIsotopesLabelLanthanidesLanthanoid Series ElementsLanthanoidsLifeLigandsLigationLinkLiverLocationMessenger RNAMetabolicMetabolic ProcessesMetabolismMetalsMethodologyMethodsMiceMice MammalsModelingMolecularMolecular ProbesMolecular TargetMonitorMultiplexed Ion Beam ImagingMurineMusNetwork AnalysisNon-Polyadenylated RNAOrganismPathway AnalysisPathway interactionsPhysiological HomeostasisPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessPropertyProtein BiosynthesisProtein ModificationProteinsRNARNA Gene ProductsReplicative SenescenceReporterRibonucleic AcidRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisSample SizeSamplingStaining methodStainsSystemT-DNATechniquesTimeTissuesWorkage associated effectsage effectage related effectsaging effectanalogautophagybarcodebiological process of agebiomonitoringcell fixationcell typedeliver short interfering RNAdeliver siRNAdeliver small interfering RNAdelivery system for siRNAdelivery system for small interfering RNAdelivery vectors for siRNAdesigndesigningdevelopmentalexperiencehepatic body systemhepatic organ systemimage-based methodimagingimaging methodimaging modalityimpact of ageinfluence of ageintervention designliver functionliving systemmRNAmetermevalonatenovelpathwayprenylationprotein synthesisrational designreplicative agingresponseself assemblysenescencesenescentsenescent cellshort interfering RNA deliverysiRNA deliverysingle cell analysissingle cell technologysmall interfering RNA deliverytherapy designtreatment design
Description preview
Summary
Different cell types, each with unique composition, properties, and functions, are essential to
sustain life in an organism. Bulk analysis of such heterogeneous mixtures of cells does not
distinguish the characteristics of a given cell type or differences between cells within the same
type, missing information that is key to understanding…
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