grant
Single Cell Methods for Bioeffector Discovery and Analysis
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 18 Dec 2018Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AccelerationAdjuvantAnti-cancer natural productsAnti-tumor Natural ProductsAntigen PresentationAntigen-Presenting CellsAntigensAssayBar CodesBioassayBiologicalBiological AssayBiologyCancer InductionCancer TreatmentCancersCell BodyCell Communication and SignalingCell DeathCell Death ProcessCell Death SignalingCell Death Signaling ProcessCell SignalingCell-Mediated Lympholytic CellsCellsCellular injuryCessation of lifeChemical AgentsChemicalsChemistryClinicalCross-PrimingCultured Neoplastic CellsCultured Tumor CellsCytolytic T-CellCytotoxic T CellCytotoxic T-LymphocytesDNADNA Intercalating AgentDataDeathDeoxyribonucleic AcidDiagnosisDrugsEngraftmentEquilibriumExposure toFamilyFinding natural productsFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGenomeGoalsHealthHumanImmuneImmune Modulation TherapyImmune mediated therapyImmunesImmunityImmunizeImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunooncologyImmunotherapyInjuryInnate Immune ResponseInnate ImmunityIntercalating AgentsIntercalating LigandsIntercalative CompoundsIntercalatorsIntracellular Communication and SignalingLytotoxicityMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMapsMeasurementMedicationMethodsMiceMice MammalsMicro-tubuleMicrotubulesMiningModalityModern ManMolecularMurineMusNative ImmunityNatural ImmunityNatural ProductsNatural anti-cancer agentsNatural antineoplastic agentsNatural chemotherapeutic agentsNatural chemotherapeutic productsNatural product anti-neoplasticsNatural product discoveryNon-Specific ImmunityNonspecific ImmunityOrganismPathway interactionsPatientsPatternPharmaceutical PreparationsPhenotypeProcessProductionProductivityPropertyResearchSignal TransductionSignal Transduction SystemsSignalingSolid NeoplasmSolid TumorStimulusStructure-Activity RelationshipSystemT-Cell ActivationT-CellsT-LymphocyteTherapeuticToxic effectToxicitiesTreatment EfficacyTumor AntigensTumor ImmunityTumor-Associated AntigenValidationVariantVariationWorkaccessory cellactivate T cellsadaptive immune responseadaptive immunityanti-cancer therapyanti-tumor immunityantitumor immunitybalancebalance functionbarcodebiologicbiological signal transductioncancer antigenscancer cellcancer immunitycancer therapycancer-directed therapycarcinogenesiscell damagecell injurycellular damagechemical structure functionchemotherapyclinical applicabilityclinical applicationcytotoxiccytotoxicitydamage to cellsdrug/agentflow cytophotometryguided discoveryguided inquiryimmune modulatory therapiesimmune modulatory treatmentimmune regulation therapyimmune regulation treatmentimmune regulatory therapyimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmune-modulation treatmentimmune-oncologyimmuno oncologyimmuno therapyimmunogenimmunogenicimmunogenic apoptosisimmunogenic cell deathimmunogenicityimmunology oncologyimmunomodulation therapyimmunomodulation treatmentimmunomodulator therapiesimmunomodulator treatmentimmunomodulator-based therapiesimmunomodulatory biologicsimmunomodulatory therapiesimmunomodulatory treatmentimmunoregulatory therapyimmunoregulatory treatmentinjuredinjuriesinjury responseinjury to cellsintervention efficacykiller T cellliving systemmalignancymetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmicrobialnaturally occurring productnecrocytosisneoplasm/cancernew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnext generationnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoncoimmunologypathwayrecruitresponse to injuryscaffoldscaffoldingsecondary metabolitesmall molecule therapeuticsstructural mutationstructural variantstructural variationstructure function relationshiptherapeutic efficacytherapeutic immunomodulationtherapeutic immunoregulationtherapy efficacythymus derived lymphocytetumortumor-specific antigenvalidations
Description preview
PROJECT SUMMARY
Natural product therapeutics remain critically important in the treatment of cancer, with most patients diagnosed
with cancer receiving natural product-based chemotherapy, such as microtubule disrupting agents and DNA
intercalators. Select chemotherapeutic small molecules, the majority of which are natural products, have an…
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