grant
Single-cell Analysis of Normal and Perturbed Dynamic and Spatial Biological Systems
Organization NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AccountingAilmentary SystemAlgorithmsAlimentary SystemAntigensB blood cellsB cellB cell growth factorB cellsB-Cell Differentiation Factor-1B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1B-CellsB-LymphocytesB-cellB7-H1BCDF-1BCGFBCGF-1BCSF 1BSF-1BSF1Bayesian ModelingBayesian adaptive designsBayesian adaptive modelsBayesian belief networkBayesian belief updating modelBayesian frameworkBayesian hierarchical modelBayesian network modelBayesian nonparametric modelsBayesian spatial data modelBayesian spatial image modelsBayesian spatial modelsBayesian statistical modelsBayesian tracking algorithmsBehaviorBeta CellBinetrakinBiologic PhenomenaBiologicalBiological FunctionBiological MarkersBiological PhenomenaBiological ProcessBiologyBlood PlasmaBody TissuesC-KIT GeneCD117CD117 AntigensCD25CD274CD68 antigenCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCOL6A1Cd68Cell BodyCell CommunicationCell Communication and SignalingCell DifferentiationCell Differentiation processCell FunctionCell InteractionCell PhysiologyCell ProcessCell SignalingCell-to-Cell InteractionCellsCells Placenta-TissueCellular FunctionCellular PhysiologyCellular ProcessCo-StimulatorColitisCollaborationsCommunicationComplexComputational toolkitCostimulatorDNA mutationDataData AnalysesData AnalysisData SetDependenceDetectionDevelopmentDevelopmental ProcessDiathesisDigestive SystemDiseaseDisease susceptibilityDisorderDrug TargetingDrugsEndocrineEndocrine systemEndocrine/Metabolic Organ SystemEnvironmental ExposureEpidermal Thymocyte Activating FactorEpithelial CellsEpitheliumExpression SignatureFOXP3FOXP3 geneForkhead Box P3GWA studyGWASGastrointestinal Body SystemGastrointestinal Organ SystemGene ActivationGene ExpressionGene Expression ProfileGene TranscriptionGenesGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenetic predisposing factorGenital systemGenomeGestationGoalsHormonal SystemIL-2IL-4IL2 ProteinIL2RIL2RAIL2RA geneIL4 ProteinIgDImmuneImmune Cell ActivationImmune responseImmune systemImmunesImmunoglobulin DImmunomodulationIndividualInfectionInflammationInflammatory Bowel DiseasesInflammatory Bowel DisorderInjuryInsulin CellInsulin Secreting CellInterleukin 2Interleukin 2 PrecursorInterleukin IIInterleukin-2Interleukin-4Interleukin-4 PrecursorInterleukine 2Interleukine 2 PrecursorInterleukine IIIntracellular Communication and SignalingJM2KO miceKnock-out MiceKnockout MiceLinkLocationLungLung Respiratory SystemLymphocyte Mitogenic FactorLymphocyte Stimulatory Factor 1MCGF-2MalariaMalignant MelanomaMalignant Tumor of the LungMalignant neoplasm of lungMapsMast Cell Growth Factor ReceptorMast Cell Growth Factor-2MeasuresMediatingMediatorMedicationMelanomaMesenchymalMetabolic/Endocrine Body SystemMethodsMiceMice MammalsMitogenic FactorModelingMurineMusMutationNK Cell ActivationNatural Killer Cell ActivationNetwork-basedNormal PlacentomaNull MouseOutcomePD-L1PDL-1PaludismPathway interactionsPerformancePharmaceutical PreparationsPhenotypePlacentaPlacenta Embryonic TissuePlacental DevelopmentPlacentationPlacentomePlasmaPlasma SerumPlasmodium InfectionsPopulationPregnancyProbabilistic ModelsProbability ModelsProcessProgrammed Cell Death 1 Ligand 1Programmed Death Ligand 1ProliferatingProteinsProto-Oncogene Protein c-kitPublicationsPublishingPulmonary Body SystemPulmonary CancerPulmonary Organ SystemPulmonary malignant NeoplasmRNA ExpressionRegulatory T-LymphocyteReproductive systemRespiratory SystemRespiratory TractsRespiratory tract structureReticuloendothelial System, Serum, PlasmaSCF ReceptorSCF Receptor GeneSCFRSCURFINScientific PublicationShapesSignal TransductionSignal Transduction SystemsSignalingSpermatogenesisStatistical ModelsStem Cell Factor ReceptorStem Cell Factor Receptor GeneSubcellular ProcessSystemSystems BiologyT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell growth factorT cell immune therapyT cell immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell ActivationT-Cell Growth FactorT-Cell Growth Factor 2T-Cell Stimulating FactorT-cell therapeuticsT-cell transfer therapyT8 CellsT8 LymphocytesTCGFRTechniquesTherapeuticThymocyte Stimulating FactorTimeTissuesTranscriptionTreesTregValidationVariantVariationVisualizationWorkactivate T cellsadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyautoencoderautoencoding neural networkbio-markersbiologicbiologic markerbiological signal transductionbiological systemsbiomarkerc kitc-kit Proteinc-kit Receptorcancer progressioncell behaviorcell imagingcell typecellular behaviorcellular differentiationcellular imagingcheck point inhibitioncheckpoint inhibitioncomputational toolboxcomputational toolscomputational toolsetcomputerized toolsdata integrationdata interpretationdata reductiondata visualizationdesigndesigningdevelopmentaldiabeticdifferential expressiondifferentially expresseddrug/agentendocrine gland/systemepithelial repairepithelial to mesenchymal transitiongastrointestinal systemgene expression patterngene expression signaturegenetic risk factorgenome mutationgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyhigh dimensional datahigh dimensionalityhost responseiPSiPSCiPSCsimmune activationimmune check point inhibitionimmune checkpoint inhibitionimmune modulationimmune regulationimmune system responseimmunogenimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimprovedinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinflammatory disease of the intestineinflammatory disorder of the intestineinherited factorinjuriesinsightinterestintestinal autoinflammationkit Proto-Oncogene Proteinliability to diseaselung cancerlymphocyte proliferationmelanoma cancer modelmelanoma modelmelanoma tumor modelmulti-modalitymultidimensional datamultidimensional datasetsmultimodalityneoplasm progressionneoplastic progressionnetwork modelsnovelp145(c-kit)p145c-kitpathwaypharmacologicprogrammed cell death ligand 1programmed cell death protein ligand 1protein death-ligand 1regulatory T-cellsreproductiverespiratoryresponsescRNA sequencingscRNA-seqsimulationsingle cell RNA-seqsingle cell RNAseqsingle cell analysissingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingspatial RNA sequencingspatial and temporalspatial gene expression analysisspatial gene expression profilingspatial integrationspatial relationshipspatial resolved transcriptome sequencingspatial temporalspatial temporal transcriptomicsspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspatiotemporalspatiotemporal gene expression analysisspatiotemporal gene expression patternsspatiotemporal transcriptomicsstatistical linear mixed modelsstatistical linear modelssynthetic datatherapeutic T-cell platformtherapeutic targettissue repairtooltranscriptional differencestranscriptional profiletranscriptional signaturetumor progressionvalidationswhole genome association analysiswhole genome association studyβ-cellβ-cellsβCell
Description preview
The aim of this project is to utilize network models as a powerful framework to investigate the complexity, spatial organization and dynamics of biological processes during development from genetic, environmental and pharmacological perturbations or exposures. In systems biology, network models provide a comprehensive understanding of the…
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