grant
Single-cell analysis and synthetic control of mammalian chromatin dynamics and gene regulation
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 5 Jul 2018Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2025AddressAgingArchitectureArtificial GenesBasal Transcription FactorBasal transcription factor genesBindingBiological FunctionBiological ProcessBiophysicsCatalogsCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCell TherapyCellsChromatinDNADNA TherapyDeoxyribonucleic AcidDevelopmentDiseaseDisorderElementsEngineering / ArchitectureEnhancersEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFluorescence Light MicroscopyFluorescence MicroscopyGene Action RegulationGene ExpressionGene Expression RegulationGene InactivationGene RegulationGene Regulation ProcessGene SilencingGene Transfer ClinicalGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic InterventionGoalsHeterogeneityHumanHuman GenomeImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune responseImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionIntracellular Communication and SignalingMath ModelsMeasurementMeasuresMethodsModelingModern ManMolecular InteractionPlayPopulationProcessProteinsRegulationRegulatory ElementRegulatory ProteinRoleSideSignal TransductionSignal Transduction SystemsSignalingSynthetic GenesTimeTranscription Factor Proto-OncogeneTranscription factor genesViralViral DiseasesViral Gene ProductsViral Gene ProteinsViral GenesViral ProteinsVirus DiseasesWorkbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencescancer progressioncatalogcell based interventioncell mediated interventioncell mediated therapiescell typecell-based therapeuticcell-based therapycellular differentiationcellular therapeuticcellular therapyco-repressorcorepressordevelopmentalepigenetic memoryepigenetic therapyepigeneticallyflow cytophotometrygene co-repressorgene corepressorgene repair therapygene therapygene-based therapygenetic co-repressorgenetic corepressorgenetic regulatory proteingenetic therapygenomic therapyhost responsehuman whole genomeimmune system responseimmunoresponsemathematic modelmathematical modelmathematical modelingneoplasm progressionneoplastic progressionpromoterpromotorregulatory gene productresponsesingle cell analysissocial rolesynthetic biologytooltranscription factortranscriptional silencingtumor progressionviral infectionvirus infectionvirus proteinvirus-induced disease
Description preview
PROJECT SUMMARY
Gene and chromatin regulation are at the core of many human biological processes such as development and
aging, and play an important role in disease, including during immune response and cancer progression. Much
work was done over the last few decades to catalogue transcription factors and chromatin regulators, determine
the gene…
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