grant

Simultaneous profiling of neuronal synapse activities, proteins, and messenger RNAs at the single-cell level

Organization MASSACHUSETTS INSTITUTE OF TECHNOLOGYLocation CAMBRIDGE, UNITED STATESPosted 30 Nov 2024Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2025ASDAccountingAffectAntibodiesAutismAutistic DisorderAutoregulationBar CodesBayesian AnalysisBayesian NetworkBayesian computationBayesian inferenceBayesian network analysisBayesian spatial analysisBayesian statistical analysisBayesian statistical inferenceBayesian statisticsBiochemistryBiologic ModelsBiological ChemistryBiological ModelsCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCalciumCausalityCell BodyCellsClustered Regularly Interspaced Short Palindromic Repeats interferenceCognitionCognition DisordersCognitiveCollaborationsCommunicationComplexDNA TherapyDevelopmentDiseaseDisorderDrug TherapyEarly Infantile AutismEtiologyFixationFutureGWA studyGWASGene DeletionGene TranscriptionGene Transfer ClinicalGenesGeneticGenetic DiseasesGenetic DiversityGenetic InterventionGenetic ScreeningGenetic TranscriptionGenetic VariationGenotypeGlutamatesHealthHereditaryHeterogeneityHomeostasisHumanImageIn SituInduced pluripotent stem cell derived human neuronInduced pluripotent stem cell derived neuronsInfantile AutismInheritedIonsKanner's SyndromeL-GlutamateMeasurementMeasuresMessenger RNAModalityModel SystemModelingModern ManMolecularNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuron from iPSCNeuron from induced pluripotent stem cellsNeuronsNeurotransmittersPathway interactionsPatientsPenetrancePharmacological TreatmentPharmacotherapyPhenotypePhysiological HomeostasisPopulationProgenitor CellsProteinsProteomicsRNA ExpressionRegulationReportingResearchResolutionRisk-associated variantRodentRodentiaRodents MammalsRoleSamplingStaining methodStainsStructureSynapsesSynapticTechniquesTestingTrainingTranscriptionTranslationsVariantVariationWorkautism spectral disorderautism spectrum disorderautistic spectrum disorderbarcodecalcium indicatorcausationcell fixingcircular RNAclosed circular RNAcognitive diseasecognitive disordercognitive syndromedevelopmentaldisease causationdrug developmentdrug interventiondrug treatmentfluorescence imagingfluorescent imaginggene deletion mutationgene repair therapygene therapygene-based therapygenetic conditiongenetic disordergenetic therapygenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic therapyglutamatergichiPSChiPSC-derived neuronshigh dimensionalityhuman iPShuman iPSChuman iPSC-derived sensory neuronhuman induced pluripotent cellhuman induced pluripotent stem cell derived sensory neuronhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsiPS neuronsiPSC derived-neuronsiPSC-derived human neuronimagingimmune imagingimmunoimaginginduced human pluripotent stem cellsinduced pluripotent stem cell neuronsinducible pluripotent stem cell derived human neuroninducible pluripotent stem cell derived human sensory neuroninterestknock-downknockdownlive cell imagelive cell imaginglive cellular imagelive cellular imagingmRNAmulti-modalitymultimodalityneurodevelopmental diseaseneuronalneuronal circuitneuronal circuitryneurons derived from induced pluripotent stem cellsneurons differentiated from human induced pluripotent stem cellsneurons differentiated from induced pluripotent stem cellsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwaypatient populationpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprospectiveprotein profilingrepressing CRISPR-dCas9 systemresolutionsresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantsample fixationschizophrenia riskscreeningscreeningssmall moleculesocial rolestem cellssynapsesynapse functionsynaptic functiontimelinetranscriptomicstranslationwhole genome association analysiswhole genome association study
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PROJECT SUMMARY
Autism spectrum disorder (ASD) is a debilitating neurodevelopmental disease that severely affects cognition
and communication in patients. Genome-wide association studies of ASD have revealed complex polygenic
variation in synapse-associated proteins. The normal development and function of neuronal circuits rely
critically on the…

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Simultaneous profiling of neuronal synapse activities, proteins, and messenger RNAs at the single-cell level — MASSACHUS | Dev Procure