grant
Silica Nephropathy and Chronic Kidney Disease of Unknown Etiology
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 7 Jul 2020Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026Acute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAffectAgricultural ChemicalsAgricultural WorkersAgricultureAgrochemicalsAirAnimal ModelAnimal Models and Related StudiesAnimalsAwardBiologicalBiopsyBloodBlood Reticuloendothelial SystemBody TemperatureBurn injuryBurnsCausalityCell BodyCell modelCellsCellular modelCentral AmericaChronicChronic DiseaseChronic IllnessChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureCirculationClinicalCommon Rat StrainsCommunicable DiseasesComplexCristobaliteDataDeath RateDehydrationDevelopmentDisparity populationDustEnvironmental EpidemiologyEnvironmental ExposureEpidemicEtiologyExposure toGoalsGuatemalaGuatemalanHarvestHealthHeat StressHeavy MetalsHistologicHistologicallyHumanHydrationHydration statusICP-MSIn VitroIndividualInductively Coupled Plasma Mass SpectrometryInfectious DiseasesInfectious DisorderInhalationInhalingInjuryInjury to KidneyInterstitial NephritisIntranasal AdministrationIntranasal Drug AdministrationKidneyKidney DiseasesKidney Urinary SystemLesionLinkLongitudinal StudiesLongitudinal SurveysLungLung Respiratory SystemMeasuresMesoamericanMexicoMiceMice MammalsMitochondriaModelingModern ManMorbidity - disease rateMurineMusNasal Lavage FluidNasal WashingNasal WashingsNephrologyNephropathyOccupational HealthOutcomeOxidation-ReductionOxidative StressOxidative Stress InductionPM2.5Particulate MatterPathologyPhysiologicPhysiologicalPreventative measurePreventive measureProteomeProteomicsRatRats MammalsRattusRecurrenceRecurrentRedoxRenal CellRenal DiseaseReportingResearchRiceRiskRisk AssessmentRisk FactorsRisk ReductionRodentRodent ModelRodentiaRodents MammalsRoleSaccharumSafetySandSeasonsSecondary toSilicaSilicon DioxideSilicosisSugarcaneTestingToxic effectToxicitiesToxicokineticsToxicologyTridymiteTubularTubular formationUnited StatesUrineacute kidney injuryagricultural communityagriculture workeramorphous silicaamorphous silicatebiologicbiomarker identificationbody water dehydrationburnedcausationchronic disorderchronic kidney diseaseco-exposuresco-occurring exposurecohortcombined exposurecomplex exposurecomputer based predictionconcurrent exposuredevelopmentaldisadvantaged groupdisadvantaged individualdisadvantaged peopledisadvantaged populationdisadvantaged subgroupdisease causationdisease riskdisorder riskdisparities across groupsdisparity across subgroupsdisparity among groupsdisparity among subgroupsdisparity between groupsdisparity between subgroupsexperienceexposure mixtureexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesfine particlesfine particulate matterglomerular sclerosisglomerulosclerosisground watergroundwatergroup disparitygroup inequalitygroup inequityhazardhigh riskidentification of biomarkersidentification of new biomarkersimprovedinequalities among populationsinequalities between populationsinequalities in populationsinequality across populationsinequality among groupsinequality between groupsinequality in groupsinequities among populationsinequities between populationsinequities in populationsinequity across groupsinequity across populationsinequity between groupsinequity in groupsinjurieskidney biopsykidney cellkidney disorderkidney injurylong-term studylongitudinal outcome studieslongitudinal research studymarker identificationmitochondrialmitochondrial dysfunctionmixed exposuremodel developmentmodel developmentsmodel of animalmorbidity ratemortalitymortality ratenano particlenano-sized particlenanoparticlenanoparticle exposurenanosized particlenew markernovelnovel biomarkernovel markeroxidation reduction reactionparticlepopulation inequalitypopulation inequitypotential biological markerpotential biomarkerpredictive modelingpulmonaryreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskrenalrenal biopsyrenal disorderrenal injuryrespiratoryrisk-reducingsimultaneous exposuressocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssubgroup disparityunequal groupunequal populationurinary
Description preview
Epidemics of chronic kidney disease of unknown etiology (CKDu) have emerged in Central America (Mesoamerican Nephropathy), in northern Sri Lanka (Sri Lankan nephropathy), in Andhra Pradesh and other regions of India (Uddanam Nephropathy), in Veracruz and Aguascalientes regions of Mexico and are emerging in the United States. In all cases, the…
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