grant
Silencing of astrocytic MAGL as a therapy for Alzheimer’s disease
Organization UNIVERSITY OF TEXAS HLTH SCIENCE CENTERLocation SAN ANTONIO, UNITED STATESPosted 15 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20262-AG2-arachidonoyl-glycerol2-arachidonoyl-sn-glycerol2-arachidonoylglycerol2-arachidonyl-glycerol2-arachidonylglycerolAAV vectorAAV-based vectorAD dementiaAD modelAD patientsAD therapyAD treatmentAccelerationAcute myocardial infarctAcute myocardial infarctionAdverse effectsAffectAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease treatmentAlzheimer sclerosisAlzheimer syndromeAlzheimer treatmentAlzheimer'sAlzheimer's DiseaseAlzheimer's disease modelAlzheimer's disease patientAlzheimer's disease therapyAlzheimer's patientAlzheimer's therapyAlzheimers DementiaAmentiaAmmon HornAnimal DiseasesAnimal ModelAnimal Models and Related StudiesAnimalsAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAstrocytesAstrocytusAstrogliaAttenuatedBody TissuesBrainBrain Nervous SystemCausalityCell BodyCellsCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalComplexCornu AmmonisDNA TherapyDegenerative Neurologic DisordersDementiaDeteriorationDevelopmentDiseaseDisease ProgressionDisorderDisturbance in cognitionDrug TherapyEarly InterventionElderlyEncephalonEndocannabinoidsEndogenous CannabinoidsEnzyme GeneEnzymesEtiologyGene ExpressionGene InactivationGene SilencingGene Transfer ClinicalGenetic InterventionGenetic studyGlycerol Monoester HydrolasesGlycerol-ester acylhydrolaseGoalsHippocampusHortega cellHumanImpaired cognitionImpairmentIncidenceInflammationInflammatoryInjectionsIntermediary MetabolismLearningLung AdenocarcinomaMT-bound tauMediatingMemoryMetabolic ProcessesMetabolismMiceMice MammalsMicrogliaModalityModern ManModificationMonoacylglycerol LipasesMonoglyceride EsterasesMonoglyceride HydrolaseMonoglyceride LipasesMotorMurineMusNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuronsOrganism-Level ProcessOrganismal ProcessOutcomePathologic ProcessesPathological ProcessesPeripheralPersonsPharmacological TreatmentPharmacotherapyPhysiologic ProcessesPhysiological ProcessesPreventionPrimary Senile Degenerative DementiaPropertySynapsesSynapticTestingTherapeuticTissuesUnited Statesadeno-associated viral vectoradeno-associated virus vectoradvanced agealzheimer modelantagonismantagonistastrocytic gliaattenuateattenuatesbone losscardiac functioncausationcell typecognitive defectscognitive dysfunctioncognitive functioncognitive lossdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldisease causationdrug interventiondrug treatmenteCB systemeffective therapyeffective treatmentefficacious interventionendocannabinoid systemendogenous cannabinoid systemfunction of the heartgene repair therapygene therapygene-based therapygenetic therapygenomic therapygeriatricgitter cellheart functionhippocampalimprovedinhibitorknock-downknockdownlipid mediatormemory retentionmesogliamicroglial cellmicrogliocytemicrotubule bound taumicrotubule-bound taumodel of animalmouse modelmurine modelneural inflammationneurodegenerative illnessneuroinflammationneuroinflammatoryneuronalneuropathologicneuropathologicalneuropathologyneuroprotectionneuroprotectiveneurotoxicnoveloverexpressoverexpressionpatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepatients with ADperivascular glial cellpharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspre-clinicalpre-clinical studypreclinicalpreclinical studypreventpreventingprimary degenerative dementiapromoterpromotorrestraintscRNA sequencingscRNA-seqsenile dementia of the Alzheimer typesenior citizensingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsynapsesynapse functionsynaptic functiontautau Proteinstau factortherapeutic outcometherapeutic targettherapy outcometranscriptional silencingvectorτ Proteins
Description preview
Summary
Dementia affects millions of people in the United States. Alzheimer’s disease (AD) is one of the most common
causes of dementia in aging. However, there are no effective therapies currently available for prevention and
treatment of AD. Therefore, it is imperative to develop novel and efficacious interventions for preventing and
treating AD…
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