grant
Signaling Pathways that Modulate Neuronal Activity
Organization FRED HUTCHINSON CANCER CENTERLocation SEATTLE, UNITED STATESPosted 1 Jan 2020Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026AdoptedAffectAfferent NeuronsAnimal BehaviorAnimalsBehaviorBehavioralBiochemicalBiologic ModelsBiological ModelsC elegansC. elegansC.elegansCaenorhabditis elegansCalciumCell Communication and SignalingCell SignalingCommunicationComplexConnector NeuronCouplingDataDefectDiseaseDisorderDysfunctionElectrophysiologyElectrophysiology (science)ElementsEsthesiaExhibitsFunctional disorderG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG Protein-Coupled Receptor Kinase FamilyG Protein-Coupled Receptor SignalingG protein coupled receptor kinaseG-Protein-Coupled ReceptorsGPCRGPCR SignalingGRKGeneticGenetic ScreeningHumanImageImpairmentIndividualIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingInvestigationKnowledgeLocomotionMediatingMethodsMindModel SystemModern ManMolecularMonitorMoodsMotorMotor CellMotor NeuronsMotor outputMovementNematodaNematodesNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurologicNeurologic DisordersNeurologicalNeurological DisordersNeuronsNeuropeptidesNeurophysiology / ElectrophysiologyOrganismOutcome StudyPathway interactionsPatternPhenotypePhosphorylationPhysiologyPhysiopathologyPlayProcessProtein FamilyProtein PhosphorylationRegulationReportingResearchRoleSensationSensorySensory NeuronsSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSpecificityStimulusSynapsesSynapticSystemTranslatingbehavior responsebehavior studybehavioral responsebehavioral studybiological signal transductionbody movementelectrophysiologicalgenetic approachgenetic strategyimagingin vitro activityin vivoinsightliving systemmotoneuronmultidisciplinarymutantneuralneural controlneural regulationneurological diseaseneuromodulationneuromodulatoryneuronalneuroregulationnovelparalogparalogous genepathophysiologypathwaypharmacologicroundwormsocial rolesulfotransferasesynapse
Description preview
Project summary
G protein-coupled receptor kinases (GRKs) play a pivotal role in modulating neuromodulatory signals by altering
GPCRs, with implications for a range of neurological and psychiatric conditions that affect sensation, mood, and
movement. The inherent complexity of the GRK protein family, characterized by several similar paralogs and…
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