grant
Signaling mechanisms of the cerebral cavernous malformations protein complex
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAddressAnimal ModelAnimal Models and Related StudiesAnkyrin Repeat-Containing Protein KRIT1ApoplexyAssayBMK1BMK1 KinaseBeliefBig MAP Kinase 1BindingBioassayBiochemicalBiologic ModelsBiological AssayBiological ModelsBlood VesselsBrachydanio rerioBrain Vascular AccidentCCM1CCM1 geneCell Communication and SignalingCell SignalingCell modelCellular modelCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCirculationComplexCryo-electron MicroscopyCryoelectron MicroscopyCrystallographiesCrystallographyDNA mutationDanio rerioDataDefectDevelopmentDiseaseDisorderERK4ERK5ERK5 KinaseElectron CryomicroscopyEmbryoEmbryonicGenesGenetic ChangeGenetic defectGenetic mutationGoalsHeartIndividualIntracellular Communication and SignalingKO miceKRIT1KinasesKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeKrev Interaction Trapped 1LaboratoriesMAP Kinase CascadesMAP Kinase Kinase KinaseMAP Kinase ModulesMAP Kinase Signaling CascadesMAP kinaseMAP kinase 7MAP3 KinasesMAPK7MAPK7 Mitogen-Activated Protein KinaseMAPK7 geneMAPKKKsMacropainMacroxyproteinaseMitogen Activated Protein Kinase 7Mitogen-Activated Protein Kinase Kinase KinasesMitogen-Activated Protein KinasesModel SystemModelingMolecularMolecular InteractionMulticatalytic ProteinaseMutationN-terminalNH2-terminalNeurologicNeurologicalNon-sense Mediated DecayNonsense-Mediated DecayNull MouseOutcomePRKM7Pathway interactionsPeptide DomainPhenotypePhosphotransferase GenePhosphotransferasesProsomeProteasomeProteasome Endopeptidase ComplexProtein DeficiencyProtein DomainsProteinsProteosomeRecurrenceRecurrentRegulationResearchRoleSeizuresSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinStrokeStructural ModelsStructureTertiary Protein StructureTestingTransphosphorylasesVascular EndotheliumZebra DanioZebra FishZebrafishbiochemical modelbiological signal transductionbiophysical analysisbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesbiophysical studiesbrain attackcerebral cavernous malformationscerebral vascular accidentcerebrovascular accidentcryo-EMcryoEMcryogenic electron microscopydeficiency of proteindevelopmentalgenome mutationloss of functionloss of function mutationmembermodel of animalmulticatalytic endopeptidase complexpathwayprotein complexprotein functionprotein protein interactionrecruitscaffoldscaffoldingsocial rolestoichiometrystrokedstrokesvascularvascular abnormality
Description preview
Multi-PI: Titus J. Boggon and David A. Calderwood
TITLE: Signaling mechanisms of the cerebral cavernous malformations protein complex
ABSTRACT
Loss of function mutations in the genes encoding KRIT1 (CCM1), CCM2 (OSM), or CCM3 (PDCD10) cause
Cerebral Cavernous Malformations (CCM). The presentation of this disease includes dilated leaky blood…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click