grant
Signaling control and cellular basis of craniofacial morphogenesis and congenital disease
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Apr 2022Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026Aberrant TissueAddressAutomobile DrivingBehaviorBirth DefectsBody TissuesCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCell Communication and SignalingCell FunctionCell IsolationCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell SegregationCell SeparationCell Separation TechnologyCell SignalingCellsCellular FunctionCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessChoristomaClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollaborationsCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCraniofacial AbnormalitiesDiseaseDisorderDysmorphologyEctopic TissueEmbryoEmbryonicEpitheliumGenetics-MutagenesisGoalsHeterotopic TissueHumanIntracellular Communication and SignalingKnowledgeLaboratoriesLearningLipLip structureMesenchymalMethodologyMiceMice MammalsModelingModern ManMolecularMorphogenesisMurineMusMutagenesisMutagenesis Molecular BiologyOperative ProceduresOperative Surgical ProceduresPatternPhysical Phenomena or PropertiesProcessResolutionSecondary PalateSeriesShapesSignal TransductionSignal Transduction SystemsSignalingSubcellular ProcessSurgicalSurgical InterventionsSurgical ProcedureSystemTechniquesTherapeuticTimeTissue EngineeringTissuesbioengineered tissuebiological signal transductioncell behaviorcell motilitycell sortingcellular behaviorcongenital anomalycraniofacialcraniofacial anomaliescraniofacial defectscraniofacial developmentcraniofacial malformationcraniofacial structurecraniofacial tissuecraniofaciescraniofrontonasal dysostosiscraniofrontonasal dysplasiacraniofrontonasal syndromedrivingengineered tissuegene regulatory networkhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsimaging platforminduced human pluripotent stem cellsmorphogenetic processnew approachesnovelnovel approachesnovel strategiesnovel strategyphysical processresolutionssurgerytool
Description preview
Project Summary
Congenital craniofacial anomalies are common and arise from cellular changes that cause aberrant tissue-level
alterations in shape. Though significant understanding of the gene regulatory networks that pattern craniofacial
development has been achieved, knowledge regarding the cellular and physical processes driving craniofacial…
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