grant
Signaling and Metabolic Regulation of Nucleotide Metabolism and Cell Growth
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AneurinBicarbonatesBiochemicalBioenergeticsCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular ExpansionCellular FunctionCellular GrowthCellular MatrixCellular PhysiologyCellular ProcessCellular biologyCitric Acid CycleComprehensionCytoskeletal SystemCytoskeletonDNA ReplicationDNA SynthesisDNA biosynthesisDevelopmentDrugsFundingGeneralized GrowthGrantGrowthHCO3HumanHydrogen CarbonatesIntermediary MetabolismIntracellular Communication and SignalingInvestigatorsKnowledgeKrebs CycleLaboratoriesMedicationMetabolicMetabolic GlycosylationMetabolic PathwayMetabolic ProcessesMetabolismMethionineMitochondriaModern ManMolecularNIGMSNational Institute of General Medical SciencesNucleotide SynthesisNucleotidesNutrient availabilityPathway interactionsPharmaceutical PreparationsPhospholipid MetabolismPhysiologyProductionProliferatingPurine NucleotidesPurinesPurines/Pyrimidines/Nucleotides/Nucleic Acids MetabolismPyrimidine NucleotidesPyruvateRNA chemical synthesisRNA methylationRNA synthesisRegulationResearchResearch PersonnelResearchersRoleSchemeScienceShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSubcellular ProcessTCA cycleThiamineTissue GrowthTricarboxylic Acid CycleVit B1Vitamin B 1Vitamin B1biological signal transductioncell biologycell growthdevelopmentaldrug/agentempowermentflexibilityflexibleforgingglycosylationhigh riskhuman diseaseinnovateinnovationinnovativeinsightintracellular skeletonmitochondrialnovelnucleotide metabolismontogenyoxidationpathwayresponsesocial rolesuccessthiamin
Description preview
PROJECT SUMMARY
Nucleotides serve as pivotal bioenergetic molecules vital for diverse cellular processes, encompassing RNA and
DNA synthesis, glycosylation, phospholipid metabolism, energy production, signaling, and cytoskeleton function.
During the past decade, my independent research has led to fundamental insights into the molecular
mechanisms…
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