grant
Signal Transduction to P70 S6 Kinase 1
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 10 Jul 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY202670-kDa Ribosomal Protein S6 KinasesAddressAdenosine Cyclic Monophosphate-Dependent Protein KinasesAffectAgingAmino AcidsAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAreaAutomobile DrivingAutoregulationBasal Transcription FactorBasal transcription factor genesBiochemicalBiogenesisBiologicalBiological FunctionBiological MarkersBiological ProcessBreast CancerCancer BiologyCancer CauseCancer Cell GrowthCancer DrugCancer EtiologyCancer ModelCancerModelCancersCatabolic ProcessCause of DeathCell BodyCell Communication and SignalingCell Growth in NumberCell MultiplicationCell NucleusCell ProliferationCell SignalingCell SurvivalCell ViabilityCellsCellular ExpansionCellular GrowthCellular Metabolic ProcessCellular ProliferationChaperoneClinicalComplexCouplingCuesCyclic AMP-Dependent Protein KinasesDNA Damage RepairDNA RepairDNA mutationDataData SetDetectionDiabetes MellitusDietDietary Fatty AcidDietary InterventionDietary PracticesDiseaseDisorderDrug TargetingDrug resistanceE-FABPEnergy-Generating ResourcesEnvironmentFABP5FABP5 geneFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2Fatty AcidsFutureGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGoalsGrantGrowthGrowth AgentsGrowth FactorGrowth SubstancesHealthHomeostasisHumanHumulin RIFNISFG-3Immune mediated therapyImmunologically Directed TherapyImmunotherapyInflammatoryInsulinInterferonsIntermediary MetabolismIntracellular Communication and SignalingInvestigationKFABPKinasesKnowledgeLinkLipidsMalignant Breast NeoplasmMalignant CellMalignant NeoplasmsMalignant TumorMechanistic Target of RapamycinMessenger RNAMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolic syndromeMetabolismModern ManMolecularMolecular ChaperonesMutationN-3 polyunsaturated fatty acidN-6 Fatty AcidsNeoplastic Disease Chemotherapeutic AgentsNon-sense Mediated DecayNonsense-Mediated DecayNovolin RNuclearNuclear AccidentsNucleusNutrientNutrition InterventionsNutritionalNutritional InterventionsO elementO2 elementObesityOmega-3 Fatty AcidsOmega-3 PUFAOmega-3 Polyunsaturated Fatty AcidOmega-6 Fatty AcidsOmega-6 PUFAsOperative ProceduresOperative Surgical ProceduresOrigin of LifeOutcomeOxygenP113PA-FABPPKAPathway interactionsPatientsPhosphoproteinsPhosphorylationPhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPhysiologyPositionPositioning AttributePre-mRNAProcessProliferatingProtein Kinase AProtein PhosphorylationProteinsProteins Growth FactorsProteomeProteomicsPublishingRAFT1RNA ExpressionRNA SplicingRNA, Messenger, PrecursorsRapamuneRapamycinRegular InsulinRegulationResistanceRoleSTAT113STAT2STAT2 geneSignal TransductionSignal Transduction SystemsSignalingSirolimusSplicingStressSurgicalSurgical InterventionsSurgical ProcedureTNBCTestingTherapeutic InterventionThesaurismosisTissue GrowthTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransphosphorylasesTumor CellTumor-Specific Treatment AgentsUnscheduled DNA SynthesisWorkadipogenesisadiposityaminoacidanti-cancer drugbio-markersbiologicbiologic markerbiological signal transductionbiomarkercAMP-Dependent Protein Kinasescancer biomarkerscancer cellcancer initiationcancer markerscancer progressioncancer sub-typescancer subtypescell growthcell metabolismcellular metabaolismchemotherapychromatin remodelingcorpulencediabetesdiet interventiondietarydietary patterndietsdrivingdrug discoverydrug resistantenergy sourceexpectationexperiencefightinggenome mutationimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprovedindividualized therapeuticinsightinterestintervention therapyknock-downknockdownlipid biosynthesislipogenesismRNAmRNA PrecursormRNA StabilitymTORmalignancymalignant breast tumormammalian target of rapamycinmetabolism disordermetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmigrationn-3 Fatty Acidsn-3 PUFAneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetnuclear disasternuclear eventnuclear incidentnutritiousomega-3omega-3sontogenyp70 S6 Kinasep70s6kpathwaypersonalized therapeuticphospho-proteomicsphosphoproteomicsprogramsresistance to Drugresistantresistant to Drugresponse to therapyresponse to treatmentscreeningscreeningssocial rolesurgerytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic biomarkertherapeutic markertherapeutic responsetherapeutic targettherapy responsetranscription factortranscriptomicstreatment programtreatment responsetreatment responsivenesstriple-negative breast cancertriple-negative invasive breast carcinomatumor progressionwestern dietwestern-style dietwestern-type dietω-6
Description preview
Project Summary. (30 lines)
Cancer is the 2nd leading cause of death in the US. The advent of new treatments such as immunotherapy and
targeted therapies have revolutionized the fight against cancer, and when combined with surgery or chemo-
therapy, often result in positive therapeutic responses. Eventually, however, most tumor cells gain the…
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