grant
Signal Integration from Membranes to the Actin Cytoskeleton
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 1 Aug 2018Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025ActinsAddressBindingBinding SitesBiochemistryBiological ChemistryBiologyCancersCell Communication and SignalingCell LocomotionCell MigrationCell MovementCell SignalingCell membraneCellular MatrixCellular MigrationCellular MotilityCollaborationsCombining SiteComplexCryo-electron MicroscopyCryoelectron MicroscopyCytoplasmic MembraneCytoskeletal SystemCytoskeletonDNA mutationDefectDevelopmentDiseaseDisorderElectron CryomicroscopyEukaryotic CellFluorescenceFluorescence Light MicroscopyFluorescence MicroscopyFoundationsGTP PhosphohydrolasesGTPasesGenetic ChangeGenetic defectGenetic mutationGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHuman PathologyImmuneImmune Cell ActivationImmunesImmunodeficiency DisorderImmunodeficiency SyndromeImmunologic Deficiency SyndromesImmunological Deficiency SyndromesIndividualInfectionInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsIntracellular Communication and SignalingKnowledgeLaboratoriesLigandsLinkMalignant NeoplasmsMalignant TumorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMolecular InteractionMonomeric G-ProteinsMonomeric GTP-Binding ProteinsMorphogenesisMutationNamesNeoplasm MetastasisNerve CellsNerve UnitNeural CellNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuronsOxidation-ReductionParasitic infectionPatientsPhosphatidyl InositolPhosphatidylinositolsPhosphoinositidesPlasma MembranePlayPolymersProcessProtein EngineeringProtein FamilyProteinsPtdInsReactive SiteReceptor ProteinRedoxRegulationResearchRoleScar1 proteinSecondary NeoplasmSecondary TumorSeriesSignal TransductionSignal Transduction SystemsSignalingSmall G-ProteinsSmall GTPasesSurface ProteinsSyndromeTherapeuticVASPVesicleWASF1WAVE proteinWAVE1 proteinWiskott Aldrich Syndrome protein family verprolin homologWiskott-Aldrich syndrome proteinWorkaxon growth cone guidanceaxon guidancebiological signal transductioncancer metastasiscell motilitycryo-EMcryoEMcryogenic electron microscopydevelopmentalexperimentexperimental researchexperimental studyexperimentsfield based datafield learningfield studyfield testgenetic protein engineeringgenome mutationguanosinetriphosphatasehuman diseaseimmune activationimmune deficiency disorderinfected with parasitesinterestintracellular skeletonmalignancymember 1 WAS protein familymembrane structuremorphogenetic processnamenamednamingneoplasm/cancerneurodevelopmental diseaseneuronalnoveloxidation reduction reactionparasite infectionparticlepathogenplasmalemmapolymerpolymericpolymerizationprotein designreceptorsingle moleculesocial roletraffickingtumor cell metastasisvasodilator-stimulated phosphoprotein
Description preview
My laboratory has a long-term interest in understanding the basic mechanisms underlying actin cytoskeleton
regulation and how these mechanisms drive fundamental processes such as cell migration, vesicle trafficking,
immune cell activation, and neuron morphogenesis. We are particularly interested in solving the regulation
mechanisms of the…
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