grant
Short Sleep Duration as a Predictor of Methamphetamine Intake: Role of Orexin Mechanisms
Organization UNIVERSITY OF MISSISSIPPI MED CTRLocation JACKSON, UNITED STATESPosted 15 Jul 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026AddressAdult femalesAdult womenAgonistBiologic FactorBiological FactorsBloodBlood Reticuloendothelial SystemBlood SerumBrainBrain Nervous SystemCircadian RhythmsCircadian desynchronyClinicalConsumptionCoupledCrystal MethCrystal methamphetamineDataDeoxyephedrineDesoxyephedrineDevelopmentDimensionsDiseaseDisorderDiurnal RhythmDoseDrug usageDrugsEEGEffectivenessElectroencephalogramElectroencephalographyEncephalonEpidemicFemaleFemales in adulthoodHcrt proteinHcrt/ORXHcrtr2 gene productHcrts/ORXsHealthHigh PrevalenceHistoryHumanIndividualInsomniaInsomnia DisorderIntakeLigandsLinkM mulattaM. mulattaMETH dependenceMETH effectMETH useMacaca mulattaMacaca rhesusMeasuresMediatorMedicationMethamphetamineMethamphetamine dependenceMethamphetamine misuseMethamphetamine use disorderMethylamphetamineModern ManMonkeysN-MethylamphetamineNyctohemeral RhythmPharmaceutical PreparationsPharmacologyPhasePhenotypePlayPrevalenceProbabilityProcessPropertyPublic HealthR-Series Research ProjectsR01 MechanismR01 ProgramReceptor ProteinRecording of previous eventsRegulationRelapseResearchResearch GrantsResearch Project GrantsResearch ProjectsRhesus MacaqueRhesus MonkeyRoleSelf AdministeredSelf AdministrationSerumSleepSleep DeprivationSleep DisordersSleep Wake CycleSleep disturbancesSleeplessnessStudy modelsSubstance Use DisorderSystemTelemetriesTelemetryTwenty-Four Hour RhythmWakefulnessWomen in adulthoodaberrant sleepactigraphactigraphyaddictionaddiction to methamphetamineaddictive disorderantagonismantagonistbehavior observationbehavioral economicsbehavioral observationcircadian desynchronizationcircadian misalignmentcircadian processcircadian rhythmicitydaily biorhythmdeficient sleepdevelopmentaldisrupted sleepdisturbed sleepdiurnal variationdrug usedrug/agentexperimentexperimental researchexperimental studyexperimentshcrt receptor 2hctr2high riskhistorieshypocretinhypocretin receptor 2 gene producthypocretin-2 receptorhypocretin/orexinhypocretins/orexinsimpaired sleepinadequate sleepinsufficient sleepirregular sleepmalemethmeth abusemeth addictionmeth misusemeth use disordermethamphetamine abusemethamphetamine addictionmethamphetamine effectmethamphetamine usenoveloresin receptor 2orexinorexin 1 receptororexin Aorexin B receptororexin receptor 2overdose deathoverdose fatalitiespoor sleeppsychosocialreceptorsleep amountsleep controlsleep debtsleep deficiencysleep deficitsleep diseasessleep disruptionsleep durationsleep dysfunctionsleep dysregulationsleep episodesleep illnesssleep insufficiencysleep intervalsleep lengthsleep losssleep periodsleep problemsleep quantitysleep regulationsleep timesleep to wake transitionsleep to wakefulness transitionsleep wakefulness cyclesleep/wake disruptionsleep/wake disturbancesleep/wake regulationsleep/wake transitionssocial rolesubstance usesubstance use and disordersubstance usingtelemetrictime asleeptime during sleeptime in sleeptime spent asleeptime spent sleepingvirtual♀♂
Description preview
Project Summary_________________________________________________________________________
Insufficient sleep predicts substance use and associated psychosocial problems, and puts individuals at a higher
risk for substance use disorders. In fact, our preliminary data suggest that the quality of overall baseline sleep
may influence methamphetamine…
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