grant

Shared Subcortical Arousal Systems Across Perceptual Modalities

Organization YALE UNIVERSITYLocation NEW HAVEN, UNITED STATESPosted 1 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AreaArousalAuditoryAwarenessBehavioralBlinkingBrainBrain Nervous SystemBrain StemBrain regionBrainstemCell Communication and SignalingCell SignalingChronicCognitionCognition DisordersDataData ReportingData SetDiseaseDisorderEncephalonEye MovementsFunctional MRIFunctional Magnetic Resonance ImagingHearingHumanImageImpairmentImplanted ElectrodesIntracellular Communication and SignalingMachine LearningMeasurementMeasuresMesencephalonMethodsMid-brainMidbrainMidbrain structureModalityModern ManPatientsPerceptionPerceptual DisordersPhasePhysiologic pulsePlayProbabilityPulsePupilRegional AnatomyReportingResolutionRoleSaccadesSaccadic Eye MovementsSaccadic PursuitSensorySignal TransductionSignal Transduction SystemsSignalingSleepStimulusSystemTactileTechniquesThalamic structureThalamusTimeTouchTouch sensationTrainingVisualVisual PerceptionWorkapplied learningbasal forebrainbiological signal transductionbiomedical implantcognitive diseasecognitive disordercognitive syndromedata representationdata representationsepilepsy participantepilepsy patientepilepsy subjectepilepsy volunteerepileptic patientepileptic subjectexperimentexperimental researchexperimental studyexperimentseye blinkeyeblinkfMRIhands-on learningimagingimplant deviceimplantable deviceimprovedindwelling deviceinteractive engagementinteractive learningmachine based learningneuralpatients with epilepsyperception disorderperceptual stimulusphysicochemical phenomena related to the sensesresolutionssensory stimulussocial roletactile sensationtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthalamictherapeutic targetvigilancevisual stimulus
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PROJECT SUMMARY / ABSTRACT
Different sensory modalities elicit distinct neural signatures in the brain, however, a fundamental subset of

circuits for perception is shared across modalities. Subcortical arousal systems are known to influence long-

lasting states such as sleep/wake and levels of vigilance, but their role in dynamic short-term…

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