grant
Sex-Specific Roles of L-PK in Cholesterol Metabolism and Atherosclerosis
Organization UNIVERSITY OF CINCINNATILocation CINCINNATI, UNITED STATESPosted 1 Jan 2024Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20251-Phosphatidylinositol 3-Kinase5 alpha-Dihydrotestosterone5-alpha-DHTAKTASCVDAccelerationActive Follow-upAddressAffectAkt proteinAnabolismAndrogen ReceptorAndrogenic AgentsAndrogenic CompoundsAndrogensAndrostanoloneAnimal ModelAnimal Models and Related StudiesAppearanceAquadiolAreaAssayAtherosclerosisAtherosclerotic Cardiovascular DiseaseBindingBioassayBioenergeticsBiological AssayBlood PlasmaC proteinCETPCETP geneCandidate Disease GeneCandidate GeneCarbonCardiac DiseasesCardiac DisordersCardiometabolic DiseaseCardiometabolic DisorderCause of DeathCell Communication and SignalingCell SignalingChIP assayCholesterolCholesterol HomeostasisCitratesCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisDataDehydrogenasesDevelopmentDihydrotestosteroneDimenformonDiogynDiogynetsDiseaseDisorderDown-RegulationEstraceEstradiolEstradiol-17 betaEstradiol-17betaEstraldineEstrogensFPLCFailureFatty LiverGWA studyGWASGene TargetingGene TranscriptionGenesGeneticGenetic DiversityGenetic ModelsGenetic TranscriptionGenetic VariationGenomic approachGenomicsGrantHDLHDL CholesterolHDL Cholesterol LipoproteinsHDL LipoproteinsHeart DiseasesHeavy LipoproteinsHepaticHepatic CellsHepatic Parenchymal CellHepatocyteHeritabilityHigh Density Lipoprotein CholesterolHigh Density LipoproteinsHuman GenomeHybridsHydrogen OxideHydroxysteroidsHypercholesteremiaHyperlipemiaHyperlipidemiaImmunoblottingInbred Strains MiceIntermediary MetabolismIntracellular Communication and SignalingLDLLDL CholesterolLDL Cholesterol LipoproteinsLDL LipoproteinsLabelLesionLipid Transfer Protein ILipidsLipoproteinsLiteratureLiverLiver CellsLiver SteatosisLow Density Lipoprotein CholesterolLow-Density LipoproteinsLuciferase ImmunologicLuciferasesMMAC1MMAC1 proteinMeasurementMeasuresMediatingMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMiceMice MammalsMitochondriaModelingMolecular InteractionMurineMusMutated in Multiple Advanced Cancers 1NAFLDNon-Polyadenylated RNANutrientOrganoidsOvocyclinOvocylinOxidoreductaseOxidoreductase GenePHTS genePHTS proteinPI-3 KinasePI3-KinasePI3CGPI3KGammaPI3kPIK3PIK3CGPIK3CG genePTENPTEN genePTEN proteinPTEN1Pathway interactionsPhenotypePhosphatase and Tensin HomologPhosphatase and Tensin Homolog Deleted on Chromosome 10Phosphatidylinositol 3-KinasePhosphatidylinositol-3-OH KinasePhosphoinositide 3-HydroxykinasePlasmaPlasma Cholesteryl Ester Transfer ProteinPlasma SerumPrebeta-LipoproteinsProcessProductionProgynonPromoter RegionsPromotor RegionsProtein Kinase BProteinsProto-Oncogene Proteins c-aktPtdIns 3-KinasePublic HealthPyruvatePyruvate KinaseRAC-PK proteinRNARNA ExpressionRNA Gene ProductsReductasesRegulationReportingReticuloendothelial System, Serum, PlasmaRibonucleic AcidRisk FactorsRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStanoloneTM Pharmacia Fast Protein Liquid ChromatographyTestingTherapeutic AndrogenTherapeutic AndrostanoloneTherapeutic EffectTherapeutic EstradiolTherapeutic EstrogenThesaurismosisTranscriptionTranslatingTriacylglycerolTriglyceridesType I Phosphatidylinositol KinaseType III Phosphoinositide 3-KinaseVLDLVLDL LipoproteinsValidationVery low density lipoproteinWaterWestern BlottingWestern Immunoblottingactive followupalpha-Lipoprotein Cholesterolalpha-Lipoproteinsandrogen dependentandrogen responsiveandrogen sensitiveatheromatosisatherosclerotic coronary diseaseatherosclerotic diseaseatherosclerotic vascular diseasebeta-Lipoprotein Cholesterolbeta-Lipoproteinsbiological signal transductionbiosynthesisc-akt proteincausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcholesterol biosynthesischolesterol metabolismchromatin immunoprecipitationcitrate carriercitrate periplasmic carrier proteincitrate transportercitrate-binding transport proteinclinical phenotypecohortcoronary arterial diseasedevelopmentalexperimentexperimental researchexperimental studyexperimentsfast protein liquid chromatographyfocus on malefocused on menfollow upfollow-upfollowed upfollowupgain of functiongene locusgene networkgenetic locusgenetic promoter elementgenetic promoter sequencegenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic effortgenomic locationgenomic locusgenomic strategyglobal gene expressionglobal transcription profileheart disorderhepatic body systemhepatic organ systemhepatic steatosishepatosteatosishiPSChigh blood cholesterolhuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshuman whole genomehypercholesterolemiaimprovedindividualized therapeuticinduced human pluripotent stem cellsinhibitorinsulin sensitivityintrahepaticknock-downknockdownlipidomicslipoprotein cholesterolliver functionloss of functionmalemale focusedmale specificmale targetedmetabolism disordermetabolism measurementmetabolomicsmetabonomicsmitochondrialmodel of animalmolecular phenotypemouse modelmultiomicsmultiple omicsmurine modelmutated in multiple advanced cancers 1 proteinnon-alcohol fatty liver diseasenon-alcoholic fatty liver diseasenon-alcoholic liver diseasenonalcoholic fatty liver diseasenoveloverexpressoverexpressionpanomicspathwaypersonalized therapeuticphenomicsphosphatase and tensin homologue on chromosome tenphosphoenol transphosphorylasephosphoenolpyruvate kinasepreferenceprogramspromoter sequenceprotein blottingproto-oncogene protein RACproto-oncogene protein aktpyr translocatorpyruvate carrierpyruvate transport proteinpyruvate transporterrac protein kinaserelated to A and C-proteinreuptakesexsocial roletargeted to mentherapeutic targettranscriptometranscriptomicstricarboxylate carriertricarboxylate transportertricarboxylate-binding C proteinuptakevalidationswestern dietwestern-style dietwestern-type dietwhole genome association analysiswhole genome association study♂
Description preview
ABSTRACT
Liver is the major hub that is responsible for regulating both plasma cholesterol and triglyceride levels as it is
involved in their synthesis, secretion, and clearance. Several studies have reported that any errors in these
processes will lead to metabolic diseases such as non-alcoholic fatty liver disease and hypercholesterolemia.…
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