grant
Sex hormones that control antibody class switching to IgG
Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026(TNF)-α19S Gamma Globulin7S Gamma GlobulinAb-mediated immunityAb-mediated protectionAbscissionAcuteAffinityAntibodiesAntibody ResponseAntibody immunityAntibody protectionAntibody-mediated protectionAntigensAntisepticsApplied GeneticsB blood cellsB cellB cell growth factorB cellsB-Cell DevelopmentB-Cell Differentiation Factor-1B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1B-CellsB-LymphocytesB-cellB220BCDF-1BCGFBCGF-1BCSF 1BSF-1BSF1BacteriaBinetrakinBlood Precursor CellBlood granulocytic cellBlood leukocyteBlood monocyteBone MarrowBone Marrow Reticuloendothelial SystemCD45CachectinCarbohydratesCell BodyCell Communication and SignalingCell SignalingCellsChimerismChromosomesChronicClass SwitchingClass SwitchingsClosure by LigationCoupledDataDifferences between sexesDiffers between sexesDoctor of PhilosophyEndocrine Gland SecretionEngraftmentEnvironmentEnvironmental FactorEnvironmental Risk FactorExcisionExposure toExtirpationFamily memberFeedbackFemaleGP180GenerationsGerminal CenterGlycansGonadal Steroid HormonesGranular LeukocytesGranulocytic cellHematopoietic Progenitor CellsHematopoietic stem cellsHormonesHumanHumoral ImmunitiesIL-4IL4 ProteinIgGIgMImmuneImmune reactionImmunesImmunityImmunochemical ImmunologicImmunoglobulin Class SwitchingImmunoglobulin Class SwitchingsImmunoglobulin GImmunoglobulin Isotype-Switch RecombinationImmunoglobulin MImmunoglobulin Switch RecombinationImmunologicImmunologicalImmunologicallyImmunologicsImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInterleukin-4Interleukin-4 PrecursorIntracellular Communication and SignalingIntrinsic factorIsotype SwitchingIsotype SwitchingsLY5LaboratoriesLeukocytesLeukocytes Reticuloendothelial SystemLigandsLigationLinkLipidsLocal Anti-Infective AgentsLymphocyte Stimulatory Factor 1MCGF-2MacrophageMacrophage-Derived TNFMarrow leukocyteMarrow monocyteMast Cell Growth Factor-2MethodsMiceMice MammalsModelingModern ManMolecularMolecular WeightMonocyte-Derived TNFMurineMusMφNeurologicNeurologicalORCHXOrchidectomyOrchiectomyOutputOvaryPTPRCPTPRC genePathway interactionsPatternPh.D.PhDPhysiologicPhysiologicalPolymersPolysaccharidesProcessProgenitor Cell TransplantationPropertyProteinsReactionReceptor ProteinRemovalSex DifferencesSex HormonesSex Steroid HormonesSexual differencesSignal TransductionSignal Transduction SystemsSignalingSpleenSpleen Reticuloendothelial SystemStem Cell TransplantationStem cell transplantStructure of germinal center of lymph nodeSurgical RemovalSwitch RecombinationSystemT-Cell Growth Factor 2T-CellsT-Independent AntigensT-LymphocyteT200TNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTNP-ficollTesticlesTestingTestisTestosteroneTherapeutic TestosteroneThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemThymus-Independent AntigensTopical Anti-Infective AgentsTrans-TestosteroneTransplantationTumor Necrosis FactorTumor Necrosis Factor-alphaViralVirusWhite Blood CellsWhite CellWorkadaptive immunityantibody-based immunityantibody-mediated immunitybiological signal transductionblood cell progenitorblood progenitorblood stem cellblood-forming stem cellcytokineenvironmental riskfungusgonadal steroidsgranulocytehematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellhuman femaleimmune suppressionimmune suppressive activityimmune suppressive functionimmunogenimmunoreactionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responsein vivolymph organlymphatic organlymphoid organmalemale gonadectomymonocytemouse modelmurine modelpathogenpathwaypolymerpolymericprogenitor transplantationpsychologicpsychologicalreceptorreconstitutereconstitutionresectionresponsesexsex based differencessex steroidsex-dependent differencessex-related differencessex-specific differencesstem and progenitor cell transplantationsthymus derived lymphocytetransplantwhite blood cellwhite blood corpuscle♀♂
Description preview
Project Summary
As a PhD candidate in the Lingwood laboratory at the Ragon institute of Mass General, MIT and Harvard, I
propose to mechanistically define how B cell class switch recombination (CSR), a core immune reaction
underscoring all humoral immunity (e.g. IgM -> IgG), is modulated by sex differences in hormones and circulating
cytokines.…
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