grant
Sex Dimorphism in Age-Related Knee Osteoarthritis
Organization SPAULDING REHABILITATION HOSPITALLocation CHARLESTOWN, UNITED STATESPosted 15 Sept 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY20252-dimensional3-D3-Dimensional3D4-vinylcyclohexene diepoxideAddressAgeAgingAnatomic SitesAnatomic structuresAnatomyAndropauseAnimal ModelAnimal Models and Related StudiesAnimalsAutomobile DrivingBasic ResearchBasic ScienceBiologic ModelsBiological ModelsBiomedical EngineeringBloodBlood PlasmaBlood Reticuloendothelial SystemBody TissuesCartilageCartilaginous TissueCell BodyCell Communication and SignalingCell DensityCell SignalingCell to Cell Communication and SignalingCell-Cell SignalingCell-Extracellular MatrixCellsChemicalsChondrocytesClinical DataClinical ResearchClinical StudyCollagenCorpus Luteum HormoneCountryData AnalysesData AnalysisDegenerative ArthritisDegenerative polyarthritisDelta4-pregnene-3,20-dioneDevelopmentDifferences between sexesDiffers between sexesDimensionsDiseaseDisease ProgressionDisorderDysfunctionECMEndocrine Gland SecretionEndocrinologyEnvironmental FactorEnvironmental Risk FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEstrogensEvaluationExtracellular MatrixFemaleFibrosisFunctional disorderGenderGeneticGoalsGonadal Steroid HormonesGonosomesHealthHormonalHormonesHumanIn VitroIncidenceIndividualInjuryIntracellular Communication and SignalingInvestigationJointsKnee OsteoarthritisLearningMaintenanceMale Change of LifeMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMedicineMenopauseMeta-AnalysisMetabolism and EndocrinologyMiceMice MammalsMidlife womenModel SystemModelingModern ManMorbidityMorbidity - disease rateMultiomic DataMurineMusMusculoskeletalNatureOlder PopulationOsteoarthritisOsteoarthrosisOutcomePathogenesisPathogenicityPathologyPatientsPhenotypePhysiologicPhysiologicalPhysiologyPhysiopathologyPlasmaPlasma SerumPost-MenopausePost-menopausal PeriodPostmenopausal PeriodPostmenopausePregn-4-ene-3,20-dionePregnenedionePrevalencePrintingProgenitor CellsProgesteroneProteomeProteomicsReticuloendothelial System, Serum, PlasmaRodentRodentiaRodents MammalsRoleSeveritiesSex ChromosomesSex DifferencesSex HormonesSex Steroid HormonesSexual differencesSignal TransductionSignal Transduction SystemsSignalingSportsSupplementationSynoviaSynovial FluidSystemTestingTherapeutic EstrogenTherapeutic HormoneTherapeutic ProgesteroneTimeTissuesUltrafiltrationWomanWorkafter menopauseage associatedage correlatedage dependentage linkedage relatedage specificagedaged groupaged groupsaged individualaged individualsaged miceaged mouseaged peopleaged personaged personsaged populationaged populationsagesaging populationbio-engineeredbio-engineersbioengineeringbiological engineeringbiological signal transductionbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesburden of diseaseburden of illnesscartilage degenerationcartilage degradationcell typedata interpretationdegenerative joint diseasedevelopmentaldisease burdendrivingeffective interventionelderly miceenvironmental riskepigeneticallyexperiencefemale at midlifefollowing menopausegonadal steroidshuman modelhypertrophic arthritisin vitro Modelin vivoinjuriesinnovateinnovationinnovativeinsightintercellular communicationknee OAknee joint OAknee joint osteoarthritislife spanlifespanmachine learned algorithmmachine learning algorithmmachine learning based algorithmmalemenmid lifemid-lifemid-life femalemiddle agemiddle agedmiddle-aged femalemiddle-aged womenmidlifemodel of animalmodel of humanmultiple omic datanew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyold miceolder groupsolder individualsolder personpast menopausepathophysiologypopulation agingpost-menopausalpostmenopausalpostmenopausal statuspreventpreventingresearch studyresponserestorationsexsex based differencessex dimorphismsex steroidsex-dependent differencessex-related differencessex-specific differencessexual dimorphismsexually dimorphicsocial rolestem cellssuccesssystematic reviewthree dimensionaltooltranscriptomicstranslational studytwo-dimensionalvinyl cyclohexene dioxidevinylcyclohexene diepoxidewomen at midlifewomen in midlife♀♂
Description preview
As indicated by the 2019 Global Burden of Disease Study, although women, on average, have a longer lifespan than men, women typically experience worsened health outcomes as they age. Notably, postmenopausal women have a higher incidence of knee osteoarthritis (KOA) and present with more severe disease progression over time. However, it is still…
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