grant
Sex differences in regulation of innate immune response by neurotransmitters
Organization UNIVERSITY OF MIAMI SCHOOL OF MEDICINELocation CORAL GABLES, UNITED STATESPosted 1 Mar 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY20264-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAminalonAminaloneAssayBasic ResearchBasic ScienceBehaviorBioassayBiological AssayBiological FunctionBiological ProcessBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood monocyteBody TissuesCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChemicalsChromosomesDiathesisDifferences between sexesDiffers between sexesDiseaseDisease susceptibilityDisorderEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExhibitsFutureGABAGender BiasGene TranscriptionGenetic TranscriptionGlutamatesGonadal Steroid HormonesHealthHormonalImmuneImmune Cell ActivationImmune responseImmunesImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInflammationInflammatoryInnate Immune ResponseIntracellular Communication and SignalingL-GlutamateLinkMarrow NeutrophilMarrow monocyteMediatorMetabolicMetadataMolecularMyeloid CellsNerve Transmitter SubstancesNeurotransmittersNeutrophilic GranulocyteNeutrophilic LeukocyteOrganism-Level ProcessOrganismal ProcessPathogenesisPathogenicityPhysiologicPhysiologic ProcessesPhysiologicalPhysiological ProcessesPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPositionPositioning AttributeProcessRNA ExpressionRegulationResolutionRoleSex BiasSex DifferencesSex HormonesSex Steroid HormonesSexual differencesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSubcellular ProcessTherapeuticTissuesTranscriptionTranslational ResearchTranslational ScienceVariantVariationWorkbiological signal transductioncomparing females and malescomparing women and menepigeneticallyfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesgamma-Aminobutyric Acidglutamatergicgonadal steroidshigh dimensionalityhost responseimmune activationimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedinflammatory modulationinsightliability to diseasemeta datamonocytemouse modelmurine modelneutrophilprogramsrepurposingresolutionsresponseresponse to therapyresponse to treatmentsexsex based differencessex steroidsex-dependent differencessex-related differencessex-specific differencessocial roletherapeutic responsetherapy responsetranscriptomicstranslation researchtranslational investigationtreatment responsetreatment responsivenesswomen compared to menwomen compared with menwomen versus menwomen vs. menγ-Aminobutyric Acid
Description preview
PROJECT SUMMARY
Sex differences in immune responses underly variation in physiological processes and disease susceptibilities.
However, there is limited insight into the sex-specific mechanisms that inform immune activation in the context
of health and disease. Monocytes and polymorphonuclear neutrophils are the first line of defense against…
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