grant
Sex differences in modulating HIV/SIV reservoirs in the context of opioids
Organization UNIVERSITY OF NEBRASKA MEDICAL CENTERLocation OMAHA, UNITED STATESPosted 1 Sept 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AIDS VirusATAC sequencingATAC-seqATACseqAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAdherenceAffectAgeAnimalsAnti-Retroviral AgentsAnti-viral ResponseAssayAssay for Transposase-Accessible Chromatin using sequencingBioassayBiologic FactorBiological AssayBiological FactorsBody TissuesBrainBrain Nervous SystemBrain regionCD11bCNS Nervous SystemCR3ACausalityCell BodyCell LineageCell NucleusCellsCentral Nervous SystemChromatinChronicClinicalControl AnimalDNA MethylationDataDependenceDifferences between sexesDiffers between sexesDrug KineticsEncephalonEndocrineEnvironmentEstrogen ReceptorsEtiologyExhibitsExposure toFemaleGene TranscriptionGenetic TranscriptionGoalsHIVHIV InfectionsHTLV-III InfectionsHTLV-III-LAV InfectionsHortega cellHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsITGAMITGAM geneImmune responseImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunologyImmunology procedureImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIndividualInfectionInfumorphKadianKineticsKnowledgeLAV-HTLV-IIILaboratoriesLocationLymph Node Reticuloendothelial SystemLymph node properLymphadenopathy-Associated VirusLymphatic TissueLymphatic nodesLymphoidLymphoid TissueM mulattaM. mulattaMAC1AMO1AMS ContinMSirMacacaMacaca mulattaMacaca rhesusMacaqueMaintenanceMath ModelsMediatingMetabolicMicrogliaModelingMolecularMorphiaMorphineMyelogenousMyeloidMyeloid CellsNeedle SharingNeuraxisNucleusOpiate AddictionOpiate DependenceOpiatesOpioidOramorphOramorph SROutcomePBMCPathogenesisPeripheralPeripheral Blood Mononuclear CellPersonsPharmacokineticsPharmacologyPlayPredispositionProcessRNA ExpressionReagentReceptor SignalingRecrudescencesRectumRelapseReportingResearchRhesus MacaqueRhesus MonkeyRoleRoxanolSIVSeriesSex DifferencesSex FactorsSexual differencesSimian Immunodeficiency VirusesSocioeconomic FactorsStatex SRStructureSubstance Use DisorderSubstance abuse problemSusceptibilitySyringe SharingSystemTechniquesTissue SampleTissuesTranscriptionVariantVariationViralViral BurdenViral LoadViral Load resultViral reservoirVirusVirus reservoirVirus-HIVWomanabuse of substancesagesanti-retroviralantiretroviral therapyantiretroviral treatmentassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingcausationchallenge in rhesus macaqueschronic paincomparing females and malescomparing women and mencravingdesigndesigningdisease causationexperiencefemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesgitter cellhost responseimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunologic assayimmunologic assay/testimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaquesinsightintegration sitelicit opioidlymph glandlymph nodeslymphnodesmalemathematic modelmathematical modelmathematical modelingmenmesogliamethylation patternmicroglial cellmicrogliocytemodel-based simulationmodels and simulationmu opioid receptorsmultiple substance abusemultisubstance abusenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyopiate abuseopiate consumptionopiate drug abuseopiate drug useopiate intakeopiate medicationopiate useopioid abuseopioid addictionopioid consumptionopioid dependenceopioid dependentopioid drug abuseopioid drug useopioid intakeopioid medicationopioid useperivascular glial cellpolysubstance abuseprescribed opiateprescribed opioidprescription opiateprescription opioidresponserhesus challengerhesus macaque challengerhesus monkey infectionsexsex based differencessex-dependent differencessex-related differencessex-specific differencessocial culturesocial rolesocio-culturalsocio-economic factorssocioculturalstemsubstance abusesubstance usesubstance use and disordersubstance usingwomen compared to menwomen compared with menwomen versus menwomen vs. menμ opioid receptorsμ-ORμOR♀♂
Description preview
Abstract
Due to the widespread use of antiretroviral therapy, HIV replication is effectively controlled in infected individuals.
However, viral reservoirs form early post-infection, posing a persistent challenge to complete virus eradication.
It has been suggested that sex differences may influence the establishment of HIV reservoirs, with…
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