grant
Sex and Leptin control of endothelial cell glycolysis and redox balance in Type 1 Diabetes
NIHUS FederalResearch GrantFY20266-Phosphofructo-2-kinase6PF2KASCVDATP-D-Fructose-6-phosphate 2-phosphotransferaseActive OxygenAortaArteriesAtherosclerosisAtherosclerotic Cardiovascular DiseaseAutoregulationBioenergeticsBlood VesselsBrittle Diabetes MellitusCRISPRCRISPR/Cas systemCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell ProtectionCell SignalingCellsCellular FunctionCellular Metabolic ProcessCellular PhysiologyCellular ProcessChromosomesClinicalClustered Regularly Interspaced Short Palindromic RepeatsComplications of Diabetes MellitusCoronary DiseaseCoronary heart diseaseCytoprotectionDataDiabetes ComplicationsDiabetes-Related ComplicationsDiabetic AngiopathiesDiabetic ComplicationsDiabetic Vascular ComplicationsDiabetic Vascular DiseasesDiabetic Vascular DisorderDiabetic macrovascular diseaseDisablingEndogenous Nitrate VasodilatorEndothelial CellsEndotheliumEndothelium-Derived Nitric OxideEnzyme GeneEnzymesEquilibriumEventExposure toFemaleFemale RolesFour Core GenotypesFructose-2,6-bisphosphataseFructose-2,6-bisphosphate 2-phosphataseGeneticGlycolysisGoalsGonadal Steroid HormonesGonosomesHeart VascularHomeostasisHousekeepingHouseworkIDDMImpairmentIndividualInsulin-Dependent Diabetes MellitusIntermediary MetabolismIntracellular Communication and SignalingJuvenile-Onset Diabetes MellitusKI miceKetosis-Prone Diabetes MellitusKnock-in MouseLeptinLifeMediatingMetabolic ProcessesMetabolismMiceMice MammalsMolecularMononitrogen MonoxideMurineMusNADPH Oxidase 1Nitric OxideNitrogen MonoxideNitrogen ProtoxideOb Gene ProductOb ProteinObese Gene ProductObese ProteinOrganellesOxidation-ReductionOxidative StressOxygen RadicalsPathologicPathway interactionsPhosphofructokinase-2PhysiologicPhysiologicalPhysiological HomeostasisPlayPre-MenopausePre-menopausal PeriodPremenopausalPremenopausal PeriodPremenopausePro-OxidantsProductionReactive Oxygen SpeciesRedoxRegulationRelaxationRoleSex ChromosomesSex HormonesSex Steroid HormonesShapesSignal TransductionSignal Transduction SystemsSignalingSourceSubcellular ProcessSudden-Onset Diabetes MellitusT1 DMT1 diabetesT1DT1DMTestingType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusUpregulationVascular DiseasesVascular DisorderVasodilatationVasodilationVasorelaxationWomanWomen's Roleadipocytokinesadipokinesatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebalancebalance functionbiological signal transductionblood vessel disordercardiovascular disordercell metabolismcell transductioncell typecellular metabaolismcellular transductioncirculatory systemcoronary disordercytoprotectivediabetic macrovascular complicationsearly onsetendothelial cell derived relaxing factorendothelial dysfunctionenvironmental stressesenvironmental stressorexpectationfemale patientsflexibilityflexiblefructose-2,6-diphosphatasegenetic approachgenetic strategygonadal steroidsinsulin dependent diabetesinsulin dependent type 1juvenile diabetesjuvenile diabetes mellitusketosis prone diabetesknockin micemalemicrovascular complications of diabetesmouse modelmurine modelnoveloxidation reduction reactionpathwaypatients being femalepatients being womenpatients who are femalepharmacologicpre-menopausalpremenopausal statuspreventpreventingprogramsprotective effectresponsesexsex steroidsocial roletransduced cellstype I diabetestype one diabetesvascularvascular dysfunctionvasculopathyvasomotionwomen patients♀♂
Description preview
PROJECT SUMMARY – PROJECT 2
The goal of Project #2 is to delineate the molecular mechanisms whereby endothelial cell (EC)
bioenergetics and, glycolysis, in particular, regulate vascular redox status and vasorelaxation in
physiological and pathological conditions with a focus on type 1 diabetes (T1D). Endothelial dysfunction
(ED) is a precursor…
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