grant
Sequencing and sample core: genetic errors of immunity
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 8 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026AllergyAutoimmune StatusAutoimmunityBioinformatics coreBioinformatics research coreBioinformatics resource coreCancersCell BodyCellsClinicalCollaborationsCommunitiesDNADNA mutationDNA seqDNA sequencingDNAseqDataData Base ManagementData Base Management SystemsData CollectionData SetDatabase Management SystemsDeoxyribonucleic AcidDiseaseDisorderEnsureFamilyGeneralized GrowthGeneticGenetic ChangeGenetic defectGenetic mutationGenetic studyGrowthHumanImmuneImmunesImmunityImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIndividualInfectionInvestigationInvestigatorsLengthLesionMalignant NeoplasmsMalignant TumorModern ManMolecular FingerprintingMolecular ProfilingMutationNGS MethodNGS systemNon-Polyadenylated RNAPBMCPenetrancePeripheral Blood Mononuclear CellPredispositionRNARNA Gene ProductsResearch PersonnelResearchersRibonucleic AcidSamplingSampling StudiesSingle cell seqSourceSusceptibilitySyndromeTissue Growthautoinflammationcomplex datadata sharingdatabase managementdatabase systemsentire genomefull genomegene signaturesgenetic signaturegenome mutationgenome sequencinghuman subjectimprovedmalignancymolecular profilemolecular signatureneoplasm/cancernext gen sequencingnext generation sequencingnextgen sequencingnovelontogenyparticipant enrollmentpatient enrollmentpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentrelational database management systemssingle cell next generation sequencingsingle cell sequencingsuccesswhole genome
Description preview
Project Summary—Core A
The exponential growth of next-generation sequencing has revolutionized the study of genetic errors of immunity.
We, as a community, have collectively identified over 500 genetic lesions leading to immune dysregulation
syndromes. These syndromes encompass susceptibility to infections, autoinflammation, autoimmunity, allergy…
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