grant
Separating the molecular determinants that govern the evolution of Orthoflavivirus NS5-mediated IFN antagonism
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 Jun 2025Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025(IFN) α(IFN)-α(IFN)αAedesAlferonAnti-viral AgentsAttenuatedAvesAvianBindingBiologyBirdsBirth DefectsBrain InflammationBreakbone Fever VirusBypassCell Communication and SignalingCell SignalingCell surfaceCharacteristicsComplexCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCoupledCryo-electron MicroscopyCryoelectron MicroscopyCulexCulex (Genus)CulicidaeDENVDNA Molecular BiologyDengue VirusDengue fever virusDisciplineDiseaseDisorderDrug TargetingEC 2.1.1EC 2.7.7.48EPH- and ELK-Related Tyrosine KinaseEPH-and ELK-Related KinaseEgypt 101 virusElectron CryomicroscopyEncephalitisEphrin Type-A Receptor 8Ephrin Type-A Receptor 8 PrecursorEvolutionFlavivirusFutureGeneralized GrowthGenetics-MutagenesisGenomeGoalsGroup B ArbovirusGrowthHistoryHost FactorHost Factor ProteinHumanIFNIFN AlphaIFN antagonistIFN αIFN-alphaRIFN-αIFN-αRIFNaIFNαImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIn VitroInfectionInnate Immune ResponseIntegration Host FactorsInterferon Alfa-n3Interferon Alpha Receptor ComplexInterferon Beta ReceptorInterferon SuppressionInterferon Type IInterferon-αInterferonsIntracellular Communication and SignalingKnowledgeLangat virusLeukocyte InterferonLymphoblast InterferonLymphoblastoid InterferonMediatingMethyltransferaseModern ManMolecularMolecular BiologyMolecular FingerprintingMolecular InteractionMolecular ProfilingMosquitoesMutagenesisMutagenesis Molecular BiologyMutateNon-structural ProteinNonstructural ProteinOrthoflavivirusOrthologOrthologous GenePathogenesisPathway interactionsPepQ proteinPersonsPhenotypeProtein Tyrosine KinaseProtein Tyrosine Kinase EEKProteinsPublic HealthRNA ReplicaseRNA replicationRNA-Dependent RNA PolymeraseRNA-Directed RNA PolymeraseRecording of previous eventsResearchRodentRodentiaRodents MammalsScientistShapesSideSignal InductionSignal Transducer and Activator of Transcription 2Signal TransductionSignal Transduction SystemsSignalingSiteSortingStat2 proteinStructureSymptomsTestingTick-Borne Encephalitis VirusTickborne Encephalitis VirusTimeTissue GrowthTransmissionTropismTyrosine KinaseTyrosine-Protein Kinase Receptor EEKTyrosine-Specific Protein KinaseTyrosylprotein KinaseViralViral ActivityViral FunctionViral Hemorrhagic FeversViral PhysiologyVirusVirus ReplicationWNVWest Nile virusWorkXaa-Pro dipeptidaseZIKVZika Virusantagonismantagonistanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsattenuateattenuatesbiological signal transductioncareercryo-EMcryoEMcryogenic electron microscopyexperimentexperimental researchexperimental studyexperimentshemorrhagic feverhistorieshydroxyaryl protein kinaseimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinterferon alpha receptorinterferon antagonistinterferon α receptormethylasemolecular profilemolecular signaturemutantnon-human primatenonhuman primateontogenypathwaypeptidase Dpressureprolidaseproline dipeptidasequiescent cell proline dipeptidasestructural biologytick-borne flavivirustick-borne virustickborne flavivirustickborne virustraining opportunitytransmethylasetransmission processtyrosyl protein kinasevaccine strategyviral multiplicationviral replicationvirologyvirus multiplicationzikav
Description preview
PROJECT SUMMARY
Flaviviruses infect up to hundreds of millions of people worldwide annually. The spectrum of diseases caused
by these viruses display a range of symptoms from mild illness to hemorrhagic fever, encephalitis, and congenital
defects. To establish infection and cause pathogenesis, viruses need to suppress their vertebrate host’s…
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