grant
Sensory Hair Cell Homeostasis
Organization NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERSLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AffectAffinityAgingApicalApoptoticAssayAuditoryAutoregulationBacteriaBindingBioassayBiochemicalBiological AssayBiophysicsCaspaseCaspase GeneCell BodyCell Communication and SignalingCell DeathCell FunctionCell Growth and MaintenanceCell MaintenanceCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCell membraneCell-Death ProteaseCellsCellular FunctionCellular MechanotransductionCellular PhysiologyCellular ProcessCellular injuryCessation of lifeCholesterolCochleaCochlear OrganComplexCorti CellCysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesCytoplasmic DomainCytoplasmic MembraneCytoplasmic TailDNA AlterationDNA Sequence AlterationDNA mutationDataDeathDevelopmentDiseaseDisorderDysfunctionEquilibriumExhibitsFunctional disorderG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGene TranscriptionGenesGenetic AlterationGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGoalsGripsHair CellsHead MovementsHealthHearingHearing DisordersHearing LossHearing problemHereditaryHomeostasisHumanHypoacusesHypoacusisICE-like proteaseImmune PrecipitationImmunoprecipitationIn VitroInfectionInheritedIntegrinsIntegrins Extracellular MatrixInterferometryInternal EarIntracellular Communication and SignalingInvestigationIon ChannelIonic ChannelsKineticsKnock-outKnockoutLabyrinthLeadLinkLipidsLiposomalLiposomesLogicMaintenanceMammaliaMammalsMechanical Signal TransductionMechanicsMechanosensory TransductionMembraneMembrane ChannelsMethodsMiceMice MammalsModelingModern ManMolecularMolecular FingerprintingMolecular InteractionMolecular ProfilingMurineMusMutationNerve Impulse TransmissionNerve TransmissionNeural DevelopmentNeuronal TransmissionOrganismPathologicPathway interactionsPb elementPhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPlasma MembranePlayPositionPositioning AttributeProcessProtein FamilyProtein FragmentProteinsPublicationsR-Series Research ProjectsR01 MechanismR01 ProgramRNA ExpressionRecyclingResearchResearch GrantsResearch Project GrantsResearch ProjectsResolutionRoleScientific PublicationScientistSensorineural DeafnessSensorineural Hearing LossSensorySensory HairSensory Hearing LossSensory PhysiologySensory ProcessSequence AlterationSignal TransductionSignal Transduction SystemsSignalingSpecificityStructural ModelsStructureSubcellular ProcessSummary ReportsSystemTherapeutic InterventionTimeTrainingTranscriptionVariantVariationVertebrate AnimalsVertebratesVestibular System FunctionVestibular functionWorkauditory diseaseauditory disorderauditory dysfunctionauditory neuropathyauditory problemaxon signalingaxon-glial signalingaxonal signalingbalancebalance disorderbalance functionbalance impairmentbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencescell damagecell injurycell typecellular damagecombatcystein proteasecystein proteinasecysteine endopeptidasedamage to cellsdeafnessdevelopmentaldisturbed balancedrug induced hearing impairmentdrug induced hearing lossdysfunctional hearingear hair cellequilibration disorderequilibrium disordergain of functiongenome mutationgenomic alterationglia signalingglial signalinggrasphearing challengedhearing defecthearing deficienthearing deficithearing difficultyhearing diseasehearing dysfunctionhearing impairmentheavy metal Pbheavy metal leadin vivo Modelinjury to cellsinner earinnovateinnovationinnovativeinsightinterdisciplinary approachintervention therapyliving systemloss of functionmechanicmechanicalmechanical cuemechanical signalmechanical stimulusmechanosensingmechanotransductionmembrane structuremolecular profilemolecular signaturemultidisciplinary approachnecrocytosisnerve signalingneural signalingneurodevelopmentneuronal signalingneurotransmissionnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnoise exposurenovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyototoxicototoxicitypathophysiologypathwayplasmalemmapostnatalprotein protein interactionreconstitutereconstitutionrepairrepairedresolutionssensorineural hearing impairmentsocial rolesoundvertebratavibration
Description preview
Mechanical cues are crucial for survival, adaptation, and normal homeostasis in almost every cell type across organisms from bacteria to vertebrates. Cells perceive mechanical stimuli through diverse mechanosensitive molecules at the cell membrane, including mechanosensitive ion channels, integrins, or G protein-coupled receptors, which activate…
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