grant
Self-Eliminating Strategy To Control Gene Drive
Organization TEXAS A&M AGRILIFE RESEARCHLocation College Station, UNITED STATESPosted 25 Jun 2020Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026A. aegyptiAbscissionAccelerationAdes aegyptiAe. AegyptiAedes aegyptiAffectAnophelesAnopheles GenusAnophelinesArboviralArbovirusesArthropod-Borne VirusesBiologic ModelsBiologicalBiological ModelsCHIKVCHIKV feverCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyChikungunya feverChikungunya virusClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCulicidaeDNA Damage RepairDNA Nicking EnzymeDNA RecombinationDNA RepairDNA Repair GeneDNA Repair PathwayDNA analysisDNA repair proteinDengueDengue FeverDengue diseaseDevelopmentDisease VectorsDrosophilaDrosophila genusDrosophila melanogasterEndonuclease IEngineeringEukaryotaEukaryoteExcisionExtirpationFliesFundingFutureGenerationsGenesGeneticGenetic RecombinationGenomeGenome engineeringGoalsGuide RNAHomingI-SceIInfrastructureInternationalKnowledgeMediatingMedicalMeiotic RecombinationMethodsModel SystemMosquito ControlMosquito-borne diseaseMosquito-borne infectious diseaseMosquitoesNickaseOutcomePerformancePopulationProcessProteinsRecombinationRemovalResearchResistanceRoleSafetySceI endonucleaseStructureSurgical RemovalSystemTechnologyTestingTransgenesTransgenic OrganismsUnscheduled DNA SynthesisWorkYellow FeverZIKV feverZika virus feveranalyze DNAbiologicbreakbone feverchromosomal locationchromosomal positionchromosome locationcommunicable disease transmissiondevelopmentaldisease controldisease transmissiondisorder controlendo.SceIendodeoxyribonuclease Sce Iendodeoxyribonuclease SceIendonucleaseexpectationexperimentexperimental researchexperimental studyexperimentsflyfruit flygRNAgene drive approachgene drive strategygene drive systemgene drive technologygene locusgenetic locusgenome analysisgenomic locationgenomic locusglobal healthhigh throughput technologyhoming driverhoming gene driveimprovedinfectious disease transmissioninnovateinnovationinnovativemalaria mosquitomalaria transmissionmeganuclease I-SceImodel organismnext-generation gene drivenovelnucleasepathogenrecruitrepairrepairedresectionresistance generesistance locusresistantresistant generesponsesocial roletooltraittransgenetransgenicvectorvector controlvector mosquitozika fever
Description preview
The ability to deliver pathogen-resistance genes into mosquito populations has long been sought as a potential
alternative for disrupting dengue or malaria transmission where funds and infrastructure are the limiting factors
in effective mosquito control. While effective gene drive transgenes based on CRISPR/Cas9 have been
developed for model…
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