grant
Self Assembled Peptide Nanoparticles as Multi-Antigen Universal Influenza Vaccines
Organization GEORGIA INSTITUTE OF TECHNOLOGYLocation ATLANTA, UNITED STATESPosted 12 Jun 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY20257S Gamma GlobulinAddressAdjuvantAntibody ResponseAntigen PresentationAntigen VariationAntigen-Presenting CellsAntigenic DeterminantsAntigenic VariabilityAntigenic VariationAntigensAvesAvianB blood cellsB cellB cell receptorB cellsB-Cell Antigen ReceptorB-CellsB-LymphocytesB-cellBinding DeterminantsBirdsBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCapsid ProteinsCoat ProteinsCold ChainsConsensus SequenceDNA mutationDataDevelopmentDisease OutbreaksDistantDoseElderlyEngineeringEpitopesExtensive DiseaseFamily suidaeFormulationGene AlterationGene MutationGeneralized DiseaseGenetic ChangeGenetic defectGenetic mutationGoalsGrippeH1N1H1N1 VirusHeadHemagglutininHumanIgAIgGImmuneImmune responseImmune systemImmunesImmunityImmunoglobulin AImmunoglobulin GInfluenzaInfluenza AInfluenza A Virus, H1N1 SubtypeInfluenza A virusInfluenza VaccinesInfluenza VirusInfluenza Viruses Type AInfluenzavirus AIntramuscularIntranasal AdministrationIntranasal Drug AdministrationLYT3LipidsMiceMice MammalsModelingModern ManMucosaMucosal ImmunityMucosal TissueMucous MembraneMurineMusMutationNucleoproteinsOrthomyxovirus Type AOutbreaksPatientsPeptidesPhylogenetic AnalysisPhylogeneticsPigsPopulationPreventative vaccinePreventive vaccinePropertyProphylactic vaccineProteinsRouteScaffolding ProteinSelf AssessmentShapesSpecificitySubunit VaccinesSuidaeSurfaceSwineT-Cell ActivationT-Cell EpitopesT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte EpitopesT-Lymphocyte SubsetsT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTissuesType A InfluenzaVaccinatedVaccinesViralViral Coat ProteinsViral Gene ProductsViral Gene ProteinsViral Outer Coat ProteinViral ProteinsVirusVirus-like particleWidespread DiseaseWorkaccessory cellactivate T cellsadvanced ageaged miceaged mouseassess effectivenesscross reactivitydeliver vaccinesdesigndesigningdetermine effectivenessdevelopmentaleffectiveness assessmenteffectiveness evaluationelderly miceevaluate effectivenessexamine effectivenessfluflu serotypeflu strainflu subtypeflu vaccineflu viral strainflu virus pandemicflu virus strainflu virus vaccinegene defectgenome mutationgeriatrichost responseimmune system responseimmunization strategyimmunogenimmunogenicimmunogenicityimmunoresponseimprovedinfluenza serotypeinfluenza straininfluenza subtypeinfluenza viral straininfluenza virus pandemicinfluenza virus straininfluenza virus vaccineinfluenzaviruslong-term memorymutant allelenano cagenano particlenano polymernano vaccinenano-sized particlenanocagenanoparticlenanopolymernanosized particlenanovaccineold micepan influenza vaccinepan influenza viral vaccinepan influenza virus vaccinepandemicpandemic diseasepandemic flupandemic influenzapandemic strain of influenzapathogenporcinepreventpreventingresponsescaffoldscaffoldingseasonal fluseasonal influenzaself assemblysenior citizensuccesssuidthymus derived lymphocytetranslational opportunitiestranslational potentialuniversal flu vaccineuniversal influenza vaccineuniversal influenza virus vaccineuniversal vaccine against fluuniversal vaccine against influenzauptakevaccination strategyvaccine against fluvaccine against influenzavaccine candidatevaccine deliveryvaccine effectivenessvaccine efficacyvaccine platformvirus proteinvirus-like nanoparticlesviruslike particle
Description preview
The goal of this proposal is to use self-assembled protein nanocages (SAPNs) as a universal flu vaccine platform
and evaluate and enhance vaccine effectiveness. Despite vaccines, seasonal influenza viruses have
continuously caused annual widespread disease and deadly flu pandemics occasionally arise. The limited
success in preventative flu…
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