grant
Selective N-alkylation of azoles via anion-binding catalysis
Organization HARVARD UNIVERSITYLocation CAMBRIDGE, UNITED STATESPosted 1 Mar 2026Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAlkylationAnionsArchitectureAreaAzolesBindingBiologicalBiologyCarbohydrate ChemistryCatalysisChemicalsChemistryClinicalComputer AnalysisDevelopmentDrug TargetingDrugsEngineering / ArchitectureExposure toH-bondHPLCHealthHigh Performance Liquid ChromatographyHigh Pressure Liquid ChromatographyHigh Speed Liquid ChromatographyHumanHydrogen BondingInvestigationIsomerismMeasurementMedicationMedicinal ChemistryMedicineMethodologyMethodsModern ManModernizationMolecular InteractionOrganic SynthesisOutcomePharmaceutic ChemistryPharmaceutical AgentPharmaceutical ChemistryPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePositionPositioning AttributePreparationPropertyReactionReportingResearchRouteStructureSynthesis ChemistrySynthetic ChemistryTechniquesThermodynamicThermodynamicsTrainingWorkanalogbasebasesbiologiccareercatalystcomputational analysescomputational analysiscomputer analysescostdesigndesigningdevelopmentaldrug candidatedrug discoverydrug/agentexperimentexperimental researchexperimental studyexperimentsinterestisomernew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapypharmaceuticalpreparationsscaffoldscaffoldingskillsstereochemistrysuccesstautomerthree dimensional
Description preview
Project Summary
Azoles are ubiquitous amongst bioactive molecules, present in approximately one third of commercial
pharmaceuticals. However, selective preparation of N-alkylated azoles is an outstanding synthetic challenge. As
a result, stereochemistry and N-regioselectivity are often achieved through the separation of isomeric mixtures
or…
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