grant
Secretory Pathway Protein Degradation Maintains Insulin Biogenesis + Secretion
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 6 Feb 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY2026Adult-Onset Diabetes MellitusAffectAnimalsAutophagocytosisAutoregulationB9 endocrine pancreasBeta CellBiogenesisBlood GlucoseBlood SugarCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCh'iChemicalsComplexCuriositiesCytoplasmic GranulesDataDefectDegradation PathwayDegradative PathwayDevelopmentDiabetes MellitusElementsEndocrine PancreasEndoplasmic ReticulumErgastoplasmFailureFamily memberGenesGeneticGrantHealthHomeostasisHumanHumulin RImpairmentInsulinInsulin CellInsulin ResistanceInsulin Secreting CellInsulin deficiencyInvestigatorsIslands of LangerhansIslets of LangerhansKetosis-Resistant Diabetes MellitusLaboratoriesLinkLysosomesMaintenanceMaturity-Onset Diabetes MellitusMediatingMembraneMessenger RNAMetabolic Protein DegradationMiceMice MammalsModelingModern ManMolecularMurineMusNIDDMNesidioblastsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin ROrigin of LifePancreasPancreaticPancreatic IsletsPancreatic beta CellPancreatic β-CellPars endocrina pancreatisPathway interactionsPhenotypePhysiological HomeostasisProcessProductionProinsulinProtein CleavageProtein PrecursorsProtein TurnoverProteinsProteolysisQiQuality ControlRegular InsulinRegulatory Protein DegradationReportingResearchResearch PersonnelResearchersRodentRodentiaRodents MammalsRouteSecretory GranulesSecretory VesiclesSlow-Onset Diabetes MellitusStable Diabetes MellitusStructure of beta Cell of isletSubcellular ProcessT2 DMT2DT2DMTRAP ComplexTRAP MediatorTRAP/Mediator ComplexTestingThyroid Hormone Receptor-Associated Protein ComplexType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUpregulationWorkadult onset diabetesautophagyblood glucose regulationdesigndesigningdevelopmentaldiabetesdisease phenotypeearly onsetfallsgene productglucose controlglucose homeostasisglucose regulationgranuleinsulin resistantinsulin toleranceisletketosis resistant diabetesmRNAmaturity onset diabetesmembrane structurenon-Nativenonnativenovelpancreas beta cellpancreas β cellpancreatic b-cellpathwaypre-proinsulinpreproinsulinprotein complexprotein degradationrecruitsigma-1 receptortraffickingtype 2 DMtype II DMtype two diabetesβ-cellβ-cellsβCell
Description preview
ABSTRACT
Pancreatic insulin mass (a combination of ß-cell mass and function in the production and storage of insulin) is
linked to blood glucose regulation. Normal islet ß-cells contain more than a billion insulin molecules per cell.
To maintain this amount involves the synthesis of ≥ 6,000 new molecules per second. Insulin synthesis begins
with…
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