grant
Sculpting Membrane Dynamics: Membrane-Remodeling Factors Shape Oligodendroglial Form and Function
Organization UNIVERSITY OF TEXAS MED BR GALVESTONLocation GALVESTON, UNITED STATESPosted 1 Mar 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2025AblationActin FilamentsActinsAction PotentialsAttenuatedAxonBehaviorBindingBinding ProteinsCNS Nervous SystemCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCell FunctionCell PhysiologyCell ProcessCell ShapeCell membraneCellsCellular FunctionCellular MatrixCellular MorphologyCellular PhysiologyCellular ProcessCentral Nervous SystemClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCo-cultureCocultivationCocultureCoculture TechniquesCompensationCytoplasmic MembraneCytoskeletal SystemCytoskeletonDataDemyelinationsDevelopmentDiseaseDisorderExhibitsExpression ProfilingFamilyFutureGenesGliaGlial CellsHeterogeneityImpairmentInjuryIntracellular MembranesKO miceKineticsKnock-outKnock-out MiceKnockoutKnockout MiceKolliker's reticulumLengthLigand Binding ProteinLigand Binding Protein GeneLoxP-flanked alleleLysolecithinsLysophosphatidylcholinesMediatingMembraneMiceMice MammalsMicrofilamentsModelingMolecularMolecular InteractionMorphogenesisMorphologyMurineMusMyelinMyelin SheathMyofilamentsNerve CellsNerve UnitNervous System InjuriesNervous System TraumaNervous System damageNeural CellNeuraxisNeurocyteNeurogliaNeuroglial CellsNeurologic DeficitNeurological DamageNeurological InjuryNeurological traumaNeuronsNon-neuronal cellNonneuronal cellNull MouseOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellPathway interactionsPlasma MembranePlayPropertyProtein BindingProtein FamilyProteinsRadialRadiusRegulationResearchRoleShapesSubcellular ProcessThickThicknessTransfectionViralamphiphysinattenuateattenuatesbehavior influencebehavioral influencebound proteincell morphologyconditional knock-outconditional knockoutdemyelinatedevelopmentalfloxedfloxed allelegain of functionin vivoinjuriesinsightintracellular skeletonloss of functionmembrane structuremorphogenetic processmouse modelmurine modelmyelinationnerve cementneural circuitneural circuitryneural repairneurocircuitryneuronalneurotraumaoligodendrocyte precursoroligodendrocyte precursor celloligodendrocyte progenitoroligodendrocyte stem celloverexpressoverexpressionpathwayplasmalemmare-myelinatere-myelinationremyelinateremyelinationsocial rolesynaptic circuitsynaptic circuitry
Description preview
Project Summary
Oligodendrocytes in the central nervous system wrap multilamellar compact myelin membranes around axons
and dramatically facilitate action potential propagation. Compromised myelination results in neurological deficits
in myelin diseases and nervous system injuries. However, myelin sheaths don't look the same. There is vast…
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