grant
Scientific Core: Animal Models
Organization SCRIPPS RESEARCH INSTITUTE, THELocation LA JOLLA, UNITED STATESPosted 1 Jun 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025AIDS VirusAIDS testAIDS/HIV testAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdjuvantAdoptive TransferAnimal ExperimentsAnimal ModelAnimal Models and Related StudiesAnimalsAntigenic DeterminantsAntigensApicalAreaB blood cellsB cellB cell receptorB cell repertoireB cellsB-Cell Antigen ReceptorB-CellsB-LymphocytesB-cellB220Binding DeterminantsBlood PlasmaBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemCD45CRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCessation of lifeClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCommunicable DiseasesDeathDevelopmentEarly-Stage Clinical TrialsEpitopesEvaluationFeedbackFormulationFrequenciesGP180GenerationsGeneticGerm LinesGlycansHIVHIV testHIV-1 testHIV-2 testHu-mABsHumanHuman Immunodeficiency VirusesHuman immunodeficiency virus testImmune GlobulinsImmune responseImmunizationImmunoglobulinsInfectionInfectious DiseasesInfectious DisorderInfrastructureInstitutionKI miceKnock-inKnock-in MouseLAV-HTLV-IIILY5LightLymphLymph Node Reticuloendothelial SystemLymph node properLymphadenopathy-Associated VirusLymphatic nodesMaintenanceMiceMice MammalsModelingModern ManMurineMusNon-Polyadenylated RNAOocytesOutputOvocytesPTPRCPTPRC genePhase 1 Clinical TrialsPhase I Clinical TrialsPhotoradiationPlasmaPlasma SerumPolysaccharidesPre-Clinical ModelPreclinical ModelsProcessProductionProteinsProtocolProtocols documentationPublic HealthRNARNA Gene ProductsReticuloendothelial System, Serum, PlasmaRibonucleic AcidRoleSamplingSpleenSpleen Reticuloendothelial SystemT200TechnologyTissuesTitrationsValidationVirus-HIVadoptive B cell therapyadoptive B cell transferanimal experimentdesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalevaluate vaccinesexperimentexperimental animalexperimental animalsexperimental researchexperimental studyexperimentshost responsehumAbshuman mAbshuman monoclonal antibodieshuman monoclonalshumanized micehumanized mouseimmune system responseimmunogenimmunoresponseimprovedknockinknockin micelymph glandlymph nodeslymphatic fluidlymphnodesmodel of animalmonomermouse modelmultiomicsmultiple omicsmurine modelpanomicsperipheral bloodphase I protocolpre-clinicalpreclinicalresponsesocial roletoolvaccine developmentvaccine evaluationvaccine screeningvaccine testingvaccinologyvalidations
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PROJECT SUMMARY
Despite advances in treatment in recent years, HIV is still responsible for more than half a million deaths
annually; new infections have, furthermore, continued to exceed the milestones set by public health institutions.
Recently, a number of candidate immunogens based on either germline targeting or epitope focusing have
moved to…
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