grant
SARS-CoV-2 Studies
Organization NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESLocation UNITED STATES
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAntibodiesAntibody ResponseBlood SampleBlood specimenCD16CD16BCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCOVID associated morbidityCOVID crisisCOVID epidemicCOVID incidenceCOVID induced morbidityCOVID morbidityCOVID pandemicCOVID related morbidityCOVID-19COVID-19 antibodyCOVID-19 associated morbidityCOVID-19 case incidenceCOVID-19 crisisCOVID-19 disease incidenceCOVID-19 epidemicCOVID-19 eraCOVID-19 exposureCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 incidenceCOVID-19 induced morbidityCOVID-19 infectionCOVID-19 morbidityCOVID-19 negativeCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 related morbidityCOVID-19 vaccinationCOVID-19 virusCOVID-19 virus infectionCOVID-19 yearsCOVID19 infectionCOVID19 negativeCOVID19 virusCV-19CoV-2CoV2Coronavirus Infectious Disease 2019CryofixationCryopreservationDataDiseaseDisorderFCGR3BFCGR3B geneFc Receptor III-1Fc gamma IIIb receptorFc-Gamma RIII-BetaFc-Gamma RIIIBFcRIIIBFrequenciesIgG Fc Receptor IIIBImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunesImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionIndividualLow Affinity IgG Fc Receptor IIIBLow Affinity Immunoglobulin Gamma Fc Region Receptor III-BMorbidityMorbidity - disease ratePBMCPeripheral Blood Mononuclear CellPredispositionPremature AgingPremature aging syndromeRegulatory T-LymphocyteSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 antibodySARS-CoV-2 epidemicSARS-CoV-2 exposureSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 incidenceSARS-CoV-2 infectionSARS-CoV-2 negativeSARS-CoV-2 pandemicSARS-CoV-2 vaccinationSARS-CoV2SARS-CoV2 exposureSARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SamplingSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 exposureSevere acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome coronavirus 2 vaccinationSevere acute respiratory syndrome related corona virus 2SmokerSmokingSusceptibilityT-Cell SubsetsT-Lymphocyte SubsetsT8 CellsT8 LymphocytesTregVaccinatedVaccinationVaccinesVisitWuhan coronavirusantibody against COVID-19antibody against SARS-CoV-2antibody against coronavirus disease 2019antibody against severe acute respiratory syndrome coronavirus 2antibody to COVID-19antibody to SARS-CoV-2antibody to coronavirus disease 2019antibody to severe acute respiratory syndrome coronavirus 2cell typecold preservationcold storagecoronavirus disease 2019coronavirus disease 2019 antibodycoronavirus disease 2019 associated morbiditycoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 exposurecoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 induced morbiditycoronavirus disease 2019 infectioncoronavirus disease 2019 morbiditycoronavirus disease 2019 negativecoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease 2019 related morbiditycoronavirus disease 2019 vaccinationcoronavirus disease 2019 viruscoronavirus disease associated morbiditycoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease induced morbiditycoronavirus disease morbiditycoronavirus disease pandemiccoronavirus disease related morbiditycoronavirus disease-19coronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccoronavirus disease-19 viruscoronavirus infectious disease-19exposure to COVID-19exposure to SARS-CoV-2exposure to SARS-CoV2exposure to Severe acute respiratory syndrome coronavirus 2exposure to coronavirus disease 2019hCoV19high riskimmune senescenceimmunosenescenceincidence rates of SARS-CoV-2 infectionincident cases of SARS-CoV-2infected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2mortalitynCoV2non-smokernonsmokerpost-COVIDpost-COVID-19post-coronavirus disease 2019prospectiveregulatory T-cellssample collectionscRNA sequencingscRNA-seqsenescencesenescentsevere acute respiratory syndrome coronavirus 2 antibodysevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsevere acute respiratory syndrome coronavirus 2 negativesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmoking exposurespecimen collectionvaccinate against COVID-19vaccinate against SARS-CoV-2vaccinate against coronavirus disease 2019vaccinate against severe acute respiratory syndrome coronavirus 2vaccination against COVID-19vaccination against SARS-CoV-2vaccination against Severe acute respiratory syndrome coronavirus 2vaccination against coronavirus disease 2019volunteer
Description preview
Smoking, Immune Senescence and COVID-19 morbidity.
The general approach is to prospectively establish a bank of cryopreserved PBMCs from smokers and nonsmokers before any COVID-19 exposure or prior to COVID-19 vaccination and to use CyTOF and single cell RNAseq to analyze detailed immune cell type profiles. Subjects will return for…
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